PT  - JOURNAL ARTICLE
AU  - Fang Fang
AU  - Wei Wang
AU  - Minhua Chen
AU  - Zhigang Tian
AU  - Weihua Xiao
TI  - Technical advances in NK cell-based cellular immunotherapy
AID  - 10.20892/j.issn.2095-3941.2019.0187
DP  - 2019 Nov 01
TA  - Cancer Biology and Medicine
PG  - 647--654
VI  - 16
IP  - 4
4099  - http://www.cancerbiomed.org/content/16/4/647.short
4100  - http://www.cancerbiomed.org/content/16/4/647.full
SO  - Cancer Biol Med2019 Nov 01; 16
AB  - Natural killer (NK) cells represent a promising future for tumor immunotherapy because of their unique biological functions and characteristics. This review focuses on technical advances in NK cell-based cellular immunotherapy and summarizes the developments of recent years in cell sources, genetic modification, manufacturing systems, clinical programs, and outcomes. Future prospects and challenges in NK cell immunotherapy are also discussed, including off-the-shelf NK cell exploitation, automatic and closed manufacturing systems, cryopreservation, and therapies involving regulatory checkpoints.