RT Journal Article
SR Electronic
T1 <em>Sex-determining region Y box-containing</em> genes: regulators and biomarkers in gynecological cancers
JF Cancer Biology and Medicine
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 462
OP 474
DO 10.20892/j.issn.2095-3941.2019.0062
VO 16
IS 3
A1 Jiali Hu
A1 Ke Li
A1 Zhanghuan Li
A1 Chao Gao
A1 Fei Guo
A1 Yingmei Wang
A1 Fengxia Xue
YR 2019
UL http://www.cancerbiomed.org/content/16/3/462.abstract
AB Sex-determining region Y box-containing genes are transcription factors with roles in multiple biological processes, including cell differentiation, proliferation, and apoptosis. Sex-determining region Y box-containing genes have also been shown to act as regulators and biomarkers in the progression of many different cancers, including gynecological cancers such as ovarian, cervical, and endometrial cancer. In this review, we summarize the contrasting regulatory roles of Sex-determining region Y box-containing genes in different gynecological cancers, as promotors with high expression levels or as suppressors with low expression levels. Expression levels of Sex-determining region Y box-containing genes were also identified as biomarkers of clinical features, including International Federation of Gynecology and Obstetrics stage, histopathologic grade together with disease-free survival, and treatment efficacy in patients with gynecological cancers. An understanding of the mechanisms whereby Sex-determining region Y box-containing genes regulate the progression of gynecological cancers will aid in the development of novel diagnostic and therapeutic strategies, while analysis of Sex-determining region Y box-containing expression levels will help to predict the prognosis of patients with gynecological cancers.