RT Journal Article
SR Electronic
T1 Adaptive response of resistant cancer cells to chemotherapy
JF Cancer Biology and Medicine
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 842
OP 863
DO 10.20892/j.issn.2095-3941.2020.0005
VO 17
IS 4
A1 Yi-Jye Chern
A1 Isabella T. Tai
YR 2020
UL http://www.cancerbiomed.org/content/17/4/842.abstract
AB Despite advances in cancer therapeutics and the integration of personalized medicine, the development of chemoresistance in many patients remains a significant contributing factor to cancer mortality. Upon treatment with chemotherapeutics, the disruption of homeostasis in cancer cells triggers the adaptive response which has emerged as a key resistance mechanism. In this review, we summarize the mechanistic studies investigating the three major components of the adaptive response, autophagy, endoplasmic reticulum (ER) stress signaling, and senescence, in response to cancer chemotherapy. We will discuss the development of potential cancer therapeutic strategies in the context of these adaptive resistance mechanisms, with the goal of stimulating research that may facilitate the development of effective cancer therapy.