PT  - JOURNAL ARTICLE
AU  - Zhe Cao
AU  - Jiangdong Qiu
AU  - Gang Yang
AU  - Yueze Liu
AU  - Wenhao Luo
AU  - Lei You
AU  - Lianfang Zheng
AU  - Taiping Zhang
TI  - MiR-135a biogenesis and regulation in malignancy: a new hope for cancer research and therapy
AID  - 10.20892/j.issn.2095-3941.2020.0033
DP  - 2020 Aug 15
TA  - Cancer Biology and Medicine
PG  - 569--582
VI  - 17
IP  - 3
4099  - http://www.cancerbiomed.org/content/17/3/569.short
4100  - http://www.cancerbiomed.org/content/17/3/569.full
SO  - Cancer Biol Med2020 Aug 15; 17
AB  - MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that affect posttranscriptional regulation by binding to the 3′-untranslated region of target messenger RNAs. MiR-135a is a critical miRNA that regulates gene expression, and many studies have focused on its function in cancer research. MiR-135a is dysregulated in various cancers and regulates cancer cell proliferation and invasion via several signaling pathways, such as the MAPK and JAK2/STAT3 pathways. MiR-135a has also been found to promote or inhibit the epithelial-mesenchymal transition and chemoresistance in different cancers. Several studies have discovered the value of miR-135a as a novel biomarker for cancer diagnosis and prognosis. These studies have suggested the potential of therapeutically manipulating miR-135a to improve the outcome of cancer patients. Although these findings have demonstrated the role of miR-135a in cancer progression and clinical applications, a number of questions remain to be answered, such as the dual functional roles of miR-135a in cancer. In this review, we summarize the available studies regarding miR-135a and cancer, including background on the biogenesis and expression of miR-135a in cancer and relevant signaling pathways involved in miR-135a-mediated tumor progression. We also focus on the clinical application of miR-135a as a biomarker in diagnosis and as a therapeutic agent or target in cancer treatment, which will provide a greater level of insight into the translational value of miR-135a.