PT  - JOURNAL ARTICLE
AU  - Li, Yanan
AU  - Xin, Jingqi
AU  - Sun, Yongbing
AU  - Han, Tao
AU  - Zhang, Hui
AU  - An, Feifei
TI  - Magnetic resonance imaging-guided and targeted theranostics of colorectal cancer
AID  - 10.20892/j.issn.2095-3941.2020.0072
DP  - 2020 May 15
TA  - Cancer Biology and Medicine
PG  - 307--327
VI  - 17
IP  - 2
4099  - http://www.cancerbiomed.org/content/17/2/307.short
4100  - http://www.cancerbiomed.org/content/17/2/307.full
SO  - Cancer Biol Med2020 May 15; 17
AB  - Colorectal cancer (CRC) is the most common gastrointestinal tract cancer worldwide and is associated with high morbidity and mortality. The development of nanosized drug delivery systems has provided a new direction in CRC treatment. Among these systems, magnetic nanoparticle (MNP)-based multifunctional platforms provide a novel strategy for magnetic resonance imaging (MRI)-related cancer theranostics. At the beginning of this original review, the carcinogenesis and treatment status of CRC are summarized. Then, diversified preparation and functionalization methods of MNPs are systematically analyzed, followed by MRI-involved theranostic strategies. The latest progress in MRI-mediated multimode diagnosis and image-guided targeted therapy in CRC management is the main focus. Finally, the major challenges in promoting MRI-induced precise theranostics of CRC in clinical practice are discussed.