RT Journal Article
SR Electronic
T1 Survival after pulmonary metastasectomy in colorectal cancer patients: does a history of resected liver metastases worsen the prognosis? A literature review
JF Cancer Biology and Medicine
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 281
OP 286
DO 10.20892/j.issn.2095-3941.2017.0073
VO 14
IS 3
A1 Jon Zabaleta
A1 Borja Aguinagalde
A1 Iker Lopez
A1 Arantza Fernandez-Monge
A1 Jose M. Izquierdo
A1 Jose I. Emparanza
YR 2017
UL http://www.cancerbiomed.org/content/14/3/281.abstract
AB Objective: To assess the impact of past liver metastases on the survival duration of patients who are undergoing surgery for lung metastases.Methods: We conducted a review of literature published from 2007 to 2014. The studies were identified by searching PubMed, MEDLINE, and Embase and were supplemented by a manual search of the references listed by the retrieved studies. The following search terms were used: lung metastasectomy, pulmonary metastasectomy, lung metastases, and lung metastasis. We selected retrospective and prospective studies published from 2007 to 2014 on patients with lung metastases from colorectal cancer and were undergoing surgery with curative intent. We excluded reviews, studies that focused on surgical techniques, patients who were treated non-surgically, analyses of specific subgroups of patients, and those that did not report follow-up of the patients undergoing surgery. Results: We identified 28 papers that assessed survival after lung metastases, 21 of which were mostly retrospective studies that identified previous liver metastases to explore their impact on patient survival. In more than half of the papers analyzed (63.2%), patients with a history of resected liver metastases had a lower survival rate than those who did not have such a history, and the difference was statistically significant in eight of these studies. However, data were presented differently, and authors reported mean survival time, survival rates, or hazard ratios. Conclusions: A history of liver metastases seems to be a negative prognostic factor, but the individual data need to undergo a meta-analysis.