RT Journal Article
SR Electronic
T1 Mesenchymal stromal cells’ role in tumor microenvironment: involvement of signaling pathways
JF Cancer Biology and Medicine
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 129
OP 141
DO 10.20892/j.issn.2095-3941.2016.0033
VO 14
IS 2
A1 Armel Herve Nwabo Kamdje
A1 Paul Takam Kamga
A1 Richard Tagne Simo
A1 Lorella Vecchio
A1 Paul Faustin Seke Etet
A1 Jean Marc Muller
A1 Giulio Bassi
A1 Erique Lukong
A1 Raghuveera Kumar Goel
A1 Jeremie Mbo Amvene
A1 Mauro Krampera
YR 2017
UL http://www.cancerbiomed.org/content/14/2/129.abstract
AB Mesenchymal stromal cells (MSCs) are adult multipotent stem cells residing as pericytes in various tissues and organs where they can differentiate into specialized cells to replace dying cells and damaged tissues. These cells are commonly found at injury sites and in tumors that are known to behave like “wounds that do not heal.” In this article, we discuss the mechanisms of MSCs in migrating, homing, and repairing injured tissues. We also review a number of reports showing that tumor microenvironment triggers plasticity mechanisms in MSCs to induce malignant neoplastic tissue formation, maintenance, and chemoresistance, as well as tumor growth. The antitumor properties and therapeutic potential of MSCs are also discussed.