PT  - JOURNAL ARTICLE
AU  - Armel Herve Nwabo Kamdje
AU  - Paul Takam Kamga
AU  - Richard Tagne Simo
AU  - Lorella Vecchio
AU  - Paul Faustin Seke Etet
AU  - Jean Marc Muller
AU  - Giulio Bassi
AU  - Erique Lukong
AU  - Raghuveera Kumar Goel
AU  - Jeremie Mbo Amvene
AU  - Mauro Krampera
TI  - Mesenchymal stromal cells’ role in tumor microenvironment: involvement of signaling pathways
AID  - 10.20892/j.issn.2095-3941.2016.0033
DP  - 2017 May 01
TA  - Cancer Biology and Medicine
PG  - 129--141
VI  - 14
IP  - 2
4099  - http://www.cancerbiomed.org/content/14/2/129.short
4100  - http://www.cancerbiomed.org/content/14/2/129.full
SO  - Cancer Biol Med2017 May 01; 14
AB  - Mesenchymal stromal cells (MSCs) are adult multipotent stem cells residing as pericytes in various tissues and organs where they can differentiate into specialized cells to replace dying cells and damaged tissues. These cells are commonly found at injury sites and in tumors that are known to behave like “wounds that do not heal.” In this article, we discuss the mechanisms of MSCs in migrating, homing, and repairing injured tissues. We also review a number of reports showing that tumor microenvironment triggers plasticity mechanisms in MSCs to induce malignant neoplastic tissue formation, maintenance, and chemoresistance, as well as tumor growth. The antitumor properties and therapeutic potential of MSCs are also discussed.