RT Journal Article
SR Electronic
T1 Single-cell analyses of circulating tumor cells
JF Cancer Biology and Medicine
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 184
OP 192
DO 10.7497/j.issn.2095-3941.2015.0056
VO 12
IS 3
A1 Chen, Xi-Xi
A1 Bai, Fan
YR 2015
UL http://www.cancerbiomed.org/content/12/3/184.abstract
AB Circulating tumor cells (CTCs) are a population of tumor cells mediating metastasis, which results in most of the cancer related deaths. The number of CTCs in the peripheral blood of patients is rare, and many platforms have been launched for detection and enrichment of CTCs. Enumeration of CTCs has already been used as a prognosis marker predicting the survival rate of cancer patients. Yet CTCs should be more potential. Studies on CTCs at single cell level may help revealing the underlying mechanism of tumorigenesis and metastasis. Though far from developed, this area of study holds much promise in providing new clinical application and deep understanding towards metastasis and cancer development.