PT  - JOURNAL ARTICLE
AU  - Xu, Yuan-Yuan
AU  - Gao, Pei
AU  - Sun, Ying
AU  - Duan, You-Rong
TI  - Development of targeted therapies in treatment of glioblastoma
AID  - 10.7497/j.issn.2095-3941.2015.0020
DP  - 2015 Sep 01
TA  - Cancer Biology and Medicine
PG  - 223--237
VI  - 12
IP  - 3
4099  - http://www.cancerbiomed.org/content/12/3/223.short
4100  - http://www.cancerbiomed.org/content/12/3/223.full
SO  - Cancer Biol Med2015 Sep 01; 12
AB  - Glioblastoma (GBM) is a type of tumor that is highly lethal despite maximal therapy. Standard therapeutic approaches provide modest improvement in progression-free and overall survival, necessitating the investigation of novel therapies. Oncologic therapy has recently experienced a rapid evolution toward “targeted therapy”, with drugs directed against specific targets which play essential roles in the proliferation, survival, and invasiveness of GBM cells, including numerous molecules involved in signal transduction pathways. Inhibitors of these molecules have already entered or are undergoing clinical trials. However, significant challenges in their development remain because several preclinical and clinical studies present conflicting results. In this article, we will provide an up-to-date review of the current targeted therapies in GBM.