[PDF][PDF] Circular RNAs: Characterization, cellular roles, and applications

CX Liu, LL Chen - Cell, 2022 - cell.com
Most circular RNAs are produced from the back-splicing of exons of precursor mRNAs.
Recent technological advances have in part overcome problems with their circular …

The biogenesis, biology and characterization of circular RNAs

LS Kristensen, MS Andersen, LVW Stagsted… - Nature reviews …, 2019 - nature.com
Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules in eukaryotes
with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by …

The expanding regulatory mechanisms and cellular functions of circular RNAs

LL Chen - Nature reviews Molecular cell biology, 2020 - nature.com
Many protein-coding genes in higher eukaryotes can produce circular RNAs (circRNAs)
through back-splicing of exons. CircRNAs differ from mRNAs in their production, structure …

[PDF][PDF] The biogenesis, functions, and challenges of circular RNAs

X Li, L Yang, LL Chen - Molecular cell, 2018 - cell.com
Covalently closed circular RNAs (circRNAs) are produced by precursor mRNA back-splicing
of exons of thousands of genes in eukaryotes. circRNAs are generally expressed at low …

[HTML][HTML] The landscape of circular RNA in cancer

JN Vo, M Cieslik, Y Zhang, S Shukla, L Xiao, Y Zhang… - Cell, 2019 - cell.com
Circular RNAs (circRNAs) are an intriguing class of RNA due to their covalently closed
structure, high stability, and implicated roles in gene regulation. Here, we used an exome …

Past, present, and future of circ RNA s

IL Patop, S Wüst, S Kadener - The EMBO journal, 2019 - embopress.org
Exonic circular RNA s (circ RNA s) are covalently closed RNA molecules generated by a
process named back‐splicing. circ RNA s are highly abundant in eukaryotes, and many of …

Biogenesis and regulatory roles of circular RNAs

L Yang, JE Wilusz, LL Chen - Annual review of cell and …, 2022 - annualreviews.org
Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes
as well as from the processing of cellular housekeeping noncoding RNAs and precursor …

[HTML][HTML] N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in …

Z Liu, T Wang, Y She, K Wu, S Gu, L Li, C Dong… - Molecular cancer, 2021 - Springer
Background An in-depth understanding of immune evasion mechanisms in tumors is crucial
to overcome resistance and enable innovative advances in immunotherapy. Circular RNAs …

[HTML][HTML] Alternative splicing and cancer: a systematic review

Y Zhang, J Qian, C Gu, Y Yang - Signal transduction and targeted …, 2021 - nature.com
The abnormal regulation of alternative splicing is usually accompanied by the occurrence
and development of tumors, which would produce multiple different isoforms and diversify …

[PDF][PDF] Structure and degradation of circular RNAs regulate PKR activation in innate immunity

CX Liu, X Li, F Nan, S Jiang, X Gao, SK Guo, W Xue… - Cell, 2019 - cell.com
Circular RNAs (circRNAs) produced from back-splicing of exons of pre-mRNAs are widely
expressed, but current understanding of their functions is limited. These RNAs are stable in …