Studies of gene rearrangements and the consequent oncogenic fusion proteins have laid
the foundation for targeted cancer therapy. To identify oncogenic fusions associated with …

Background RNA-seq has spurred important gene fusion discoveries in a number of
different cancers, including lung, prostate, breast, brain, thyroid and bladder carcinomas …

Transcript fusions as a result of chromosomal rearrangements have been a focus of
attention in cancer as they provide attractive therapeutic targets. To identify novel fusion …

Fusion genes are chromosomal aberrations that are found in many cancers and can be
used as prognostic markers and drug targets in clinical practice. Fusions can lead to …

Gene fusions represent an important class of somatic alterations in cancer. We
systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple …

Gene fusion is one of the hallmarks of cancer genome via chromosomal rearrangement
initiated by DNA double-strand breakage. To date, many fusion genes (FGs) have been …

Gene fusions, like BCR/ABL1 in chronic myelogenous leukemia, have long been recognized
in hematologic and mesenchymal malignancies. The recent finding of gene fusions in …

Glioblastoma multiforme is the most common tumor arising in the central nervous system.
Patients with these tumors have limited treatment options and their disease is invariably …

Malignant gliomas are heterogeneous diseases in genetic basis. The development of
sequencing techniques has identified many gene rearrangements encoding novel …

Enabled by high-throughput sequencing approaches, epithelial cancers across a range of
tissue types are seen to harbor gene fusions as integral to their landscape of somatic …