Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma

M Castellarin, RL Warren, JD Freeman… - Genome …, 2012 - genome.cshlp.org
An estimated 15% or more of the cancer burden worldwide is attributable to known
infectious agents. We screened colorectal carcinoma and matched normal tissue specimens …

[HTML][HTML] Colon Cancer-Associated Fusobacterium nucleatum May Originate From the Oral Cavity and Reach Colon Tumors via the Circulatory System

J Abed, N Maalouf, AL Manson, AM Earl… - Frontiers in cellular …, 2020 - frontiersin.org
Fusobacterium nucleatum is a common oral bacterium that is enriched in colorectal
adenomas and adenocarcinomas (CRC). In humans, high fusobacterial CRC abundance is …

Fusobacterium in Colonic Flora and Molecular Features of Colorectal Carcinoma

T Tahara, E Yamamoto, H Suzuki, R Maruyama… - Cancer research, 2014 - AACR
Fusobacterium species are part of the gut microbiome in humans. Recent studies have
identified overrepresentation of Fusobacterium in colorectal cancer tissues, but it is not yet …

Genomic analysis identifies association of Fusobacterium with colorectal carcinoma

AD Kostic, D Gevers, CS Pedamallu… - Genome …, 2012 - genome.cshlp.org
The tumor microenvironment of colorectal carcinoma is a complex community of genomically
altered cancer cells, nonneoplastic cells, and a diverse collection of microorganisms. Each …

Fusobacterium nucleatum — symbiont, opportunist and oncobacterium

CA Brennan, WS Garrett - Nature Reviews Microbiology, 2019 - nature.com
Fusobacterium nucleatum has long been found to cause opportunistic infections and has
recently been implicated in colorectal cancer; however, it is a common member of the oral …

Southern Chinese populations harbour non-nucleatum Fusobacteria possessing homologues of the colorectal cancer-associated FadA virulence factor

YK Yeoh, Z Chen, MCS Wong, M Hui, J Yu, SC Ng… - Gut, 2020 - gut.bmj.com
Objective Fusobacteria are not common nor relatively abundant in non-colorectal cancer
(CRC) populations, however, we identified multiple Fusobacterium taxa nearly absent in …

[HTML][HTML] Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment

AD Kostic, E Chun, L Robertson, JN Glickman… - Cell host & …, 2013 - cell.com
Increasing evidence links the gut microbiota with colorectal cancer. Metagenomic analyses
indicate that symbiotic Fusobacterium spp. are associated with human colorectal carcinoma …

Human Microbiome Fusobacterium Nucleatum in Esophageal Cancer Tissue Is Associated with Prognosis

K Yamamura, Y Baba, S Nakagawa, K Mima… - Clinical Cancer …, 2016 - AACR
Purpose: Fusobacterium nucleatum (F. nucleatum) is a component of the human
microbiome that primarily inhabits the oral cavity. It causes periodontal disease and has also …

Comparative analysis of colon cancer-derived fusobacterium nucleatum subspecies: inflammation and colon tumorigenesis in murine models

J Queen, JC Domingue, JR White, C Stevens… - MBio, 2022 - Am Soc Microbiol
Fusobacteria are commonly associated with human colorectal cancer (CRC), but
investigations are hampered by the absence of a stably colonized murine model. Further …

RNA landscape of the emerging cancer-associated microbe Fusobacterium nucleatum

F Ponath, C Tawk, Y Zhu, L Barquist, F Faber… - Nature …, 2021 - nature.com
Fusobacterium nucleatum, long known as a constituent of the oral microflora, has recently
garnered renewed attention for its association with several different human cancers. The …