Next-generation DNA sequencing (NGS) projects, such as the 1000 Genomes Project, are
already revolutionizing our understanding of genetic variation among individuals. However …

Advancements in next generation sequencing (NGS) technologies have significantly
increased the translational use of genomics data in the medical field as well as the demand …

Motivation: Post-sequencing DNA analysis typically consists of read mapping followed by
variant calling. Especially for whole genome sequencing, this computational step is very …

Abstract Background Next-Generation Sequencing (NGS) has emerged as a widely used
tool in molecular biology. While time and cost for the sequencing itself are decreasing, the …

Background With the decreasing cost of sequencing and the rapid developments in
genomics technologies and protocols, the need for validated bioinformatics software that …

Many time-consuming analyses of next-generation sequencing data can be addressed with
modern cloud computing. The Apache Hadoop-based solutions have become popular in …

Motivation: The advent of high-throughput sequencing (HTS) technologies has made it
affordable to sequence many individuals' genomes. Simultaneously the computational …

Abstract Background SAMtools and BCFtools are widely used programs for processing and
analysing high-throughput sequencing data. They include tools for file format conversion …

SUMMARY We describe Globus Genomics, a system that we have developed for rapid
analysis of large quantities of next‐generation sequencing genomic data. This system …

Background The emergence of high throughput technologies that produce vast amounts of
genomic data, such as next-generation sequencing (NGS) is transforming biological …