The human gut microbiota is engaged in multiple interactions affecting host health during
the host's entire life span. Microbes colonize the neonatal gut immediately following birth …

Isothermal amplification of nucleic acids is a simple process that rapidly and efficiently
accumulates nucleic acid sequences at constant temperature. Since the early 1990s …

The lion's share of bacteria in various environments cannot be cloned in the laboratory and
thus cannot be sequenced using existing technologies. A major goal of single-cell genomics …

Dementia in Alzheimer's disease progresses alongside neurodegeneration,,–, but the
specific events that cause neuronal dysfunction and death remain poorly understood. During …

Rolling circle amplification (RCA) is an isothermal enzymatic process where a short DNA or
RNA primer is amplified to form a long single stranded DNA or RNA using a circular DNA …

Kindred cells can have different genomes because of dynamic changes in DNA. Single-cell
sequencing is needed to characterize these genomic differences but has been hindered by …

It has long been hypothesized that aging and neurodegeneration are associated with
somatic mutation in neurons; however, methodological hurdles have prevented testing this …

The field of single-cell genomics is advancing rapidly and is generating many new insights
into complex biological systems, ranging from the diversity of microbial ecosystems to the …

High-throughput sequencing, also known as next-generation sequencing (NGS), has
revolutionized genomic research. In recent years, NGS technology has steadily improved …

Fundamental to most genetic analysis is availability of genomic DNA of adequate quality
and quantity. Because DNA yield from human samples is frequently limiting, much effort has …