Cancer-induced angiogenesis is the result of increased expression of angiogenic factors, or
decreased expression of anti-angiogenic factors, or a combination of both events. For …

The present paper reviews current concepts on the role of cyclooxygenase (COX) in the
development of malignant tumors. An inducible isoform of cyclooxygenase is expressed in …

Abstract Cyclooxygenase-2 (COX-2) is an immediate early response gene that can be
induced by a variety of tumor promoters, cytokines, growth factors and hypoxia. COX-2 …

Cyclooxygenase-2 (COX-2; Ptgs2) acts as a tumor promoter in rodent models for colorectal
cancer, but its precise role in carcinogenesis remains unclear. We evaluated the contribution …

It seems certain that COX-2 is related to tumor and some data suggested that COX-2 might
have relation to tumor malignance and angiogenesis. In order to elucidate the relationship …

BACKGROUND & AIMS:: Recent studies have shown that cyclooxygenase (COX)-2 and its
products, prostaglandins (PGs), may be involved in colorectal carcinogenesis. The aim of …

We provide evidence that cyclooxygenase (COX)-2-derived prostaglandins contribute to
tumor growth by inducing newly formed blood vessels (neoangiogenesis) that sustain tumor …

Although gastric cancer with cyclooxygenase (COX)-2 overexpression is associated with
poor prognosis, the mechanistic pathway remains unknown. We examined the associations …

In vitro studies suggest that cyclooxygenase-2 (COX-2) induces angiogenesis by stimulating
angiogenic growth factors while inhibiting apoptosis in cancer cell lines. A series of 107 …

BACKGROUND Nonsteroidal antiinflammatory drugs inhibiting cyclooxygenase (COX)
enzyme activity in both its constitutive (COX‐1) and inducible (COX‐2) isoforms were shown …