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A bispecific EGFR × HER3 antibody–drug conjugate for later-line recurrent or metastatic nasopharyngeal carcinoma: insights from BL-B01D1-303

Huaqiang Zhou, Jiayi Shen, Jiaqing Liu, Li Zhang and Yunpeng Yang
Cancer Biology & Medicine September 2026, 20260336; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0336
Huaqiang Zhou
Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
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Jiayi Shen
Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
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Jiaqing Liu
Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
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Li Zhang
Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
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  • For correspondence: zhangli{at}sysucc.org.cn yangyp{at}sysucc.org.cn
Yunpeng Yang
Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
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  • For correspondence: zhangli{at}sysucc.org.cn yangyp{at}sysucc.org.cn
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Article Information

20260336
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2026.0336

Published By 
Cancer Biology & Medicine
History 
  • Received April 28, 2026
  • Accepted August 13, 2026
  • Published online September 23, 2026.

Copyright & Usage 
Copyright: © 2026, The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Author Information

Funding

  • Young Talents Program of Sun Yat-sen University Cancer Center

    YTP-SYSUCC-0096 to H. Zhou

This work was supported by a grant from the Young Talents Program of Sun Yat-sen University Cancer Center (Grant No. YTP-SYSUCC-0096 to H. Zhou).

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Cancer Biology & Medicine: 23 (9)
Cancer Biology & Medicine
Vol. 23, Issue 9
15 Sep 2026
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A bispecific EGFR × HER3 antibody–drug conjugate for later-line recurrent or metastatic nasopharyngeal carcinoma: insights from BL-B01D1-303
Huaqiang Zhou, Jiayi Shen, Jiaqing Liu, Li Zhang, Yunpeng Yang
Cancer Biology & Medicine Sep 2026, 20260336; DOI: 10.20892/j.issn.2095-3941.2026.0336

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A bispecific EGFR × HER3 antibody–drug conjugate for later-line recurrent or metastatic nasopharyngeal carcinoma: insights from BL-B01D1-303
Huaqiang Zhou, Jiayi Shen, Jiaqing Liu, Li Zhang, Yunpeng Yang
Cancer Biology & Medicine Sep 2026, 20260336; DOI: 10.20892/j.issn.2095-3941.2026.0336
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  • Article
    • Defining the later-line treatment landscape
    • BL-B01D1-303 in later-line NPC: established efficacy and unresolved issues
    • Iza-bren in later-line NPC: managing hematologic toxicity and refining patient selection
    • Rationale for an EGFR × HER3 bispecific ADC and its limitations
    • ADC selection in R/M NPC: beyond response rates
    • Predictive biomarkers and treatment sequencing for ADCs in NPC: unresolved issues
    • Later-line NPC in the ADC era: what comes next?
    • Conclusions
    • Conflict of interest statement
    • Author contributions
    • References
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