Research ArticleOriginal Article
Open Access
Apatinib enhances targeted immunotherapy via the IL-6-gp130-PI3K pathway in HER2-positive gastric cancer
Ruoxi Tian, Ziyue Sha, Shasha Zhang, Miao Gong, Jianhua Wu, Juntao Lu, Wei Guo, Zhaoxu Zheng and Zhanjun Guo
Cancer Biology & Medicine July 2026, 20250687; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0687
Ruoxi Tian
1Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100000, China
Ziyue Sha
2Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
Shasha Zhang
2Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
Miao Gong
3Department of Histology and Embryology, College of Basic Medicine, Hebei Medical University, Shijiazhuang 050000, China
Jianhua Wu
4Animal Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
Juntao Lu
5Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
Wei Guo
5Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
Zhaoxu Zheng
1Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100000, China
Zhanjun Guo
2Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China

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In this issue
Apatinib enhances targeted immunotherapy via the IL-6-gp130-PI3K pathway in HER2-positive gastric cancer
Ruoxi Tian, Ziyue Sha, Shasha Zhang, Miao Gong, Jianhua Wu, Juntao Lu, Wei Guo, Zhaoxu Zheng, Zhanjun Guo
Cancer Biology & Medicine Jul 2026, 20250687; DOI: 10.20892/j.issn.2095-3941.2025.0687
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