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Research ArticleOriginal Article
Open Access

Apatinib enhances targeted immunotherapy via the IL-6-gp130-PI3K pathway in HER2-positive gastric cancer

Ruoxi Tian, Ziyue Sha, Shasha Zhang, Miao Gong, Jianhua Wu, Juntao Lu, Wei Guo, Zhaoxu Zheng and Zhanjun Guo
Cancer Biology & Medicine July 2026, 20250687; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0687
Ruoxi Tian
1Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100000, China
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Ziyue Sha
2Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
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Shasha Zhang
2Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
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Miao Gong
3Department of Histology and Embryology, College of Basic Medicine, Hebei Medical University, Shijiazhuang 050000, China
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Jianhua Wu
4Animal Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
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Juntao Lu
5Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
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Wei Guo
5Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
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Zhaoxu Zheng
1Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100000, China
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  • ORCID record for Zhaoxu Zheng
  • For correspondence: zzx_20003{at}126.com zjguo5886{at}hebmu.edu.cn
Zhanjun Guo
2Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
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  • ORCID record for Zhanjun Guo
  • For correspondence: zzx_20003{at}126.com zjguo5886{at}hebmu.edu.cn
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Article Information

20250687
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2025.0687

Published By 
Cancer Biology & Medicine
History 
  • Received November 14, 2025
  • Accepted May 25, 2026
  • Published online July 30, 2026.

Article Versions

  • previous version (July 20, 2026 - 06:22).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright: © 2026, The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Author Information

  1. Ruoxi Tian1,
  2. Ziyue Sha2,
  3. Shasha Zhang2,
  4. Miao Gong3,
  5. Jianhua Wu4,
  6. Juntao Lu5,
  7. Wei Guo5,
  8. Zhaoxu Zheng1⇑ and
  9. Zhanjun Guo2⇑
  1. 1Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100000, China
  2. 2Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
  3. 3Department of Histology and Embryology, College of Basic Medicine, Hebei Medical University, Shijiazhuang 050000, China
  4. 4Animal Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
  5. 5Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
  1. Correspondence to: Zhaoxu Zheng and Zhanjun Guo, E-mail: zzx_20003{at}126.com and zjguo5886{at}hebmu.edu.cn
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Funding

  • Central Government Guides Local Funds Supported by the S&T Program of Hebei

    246Z7741G
  • The Beijing Science and Technology Medical Development Foundation

    KC2024-JX-0189

This study was funded by the Central Government Guides Local Funds Supported by the S&T Program of Hebei (Grant No. 246Z7741G), and The Beijing Science and Technology Medical Development Foundation (Grant No. KC2024-JX-0189).

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Cancer Biology & Medicine: 23 (7)
Cancer Biology & Medicine
Vol. 23, Issue 7
15 Jul 2026
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Apatinib enhances targeted immunotherapy via the IL-6-gp130-PI3K pathway in HER2-positive gastric cancer
Ruoxi Tian, Ziyue Sha, Shasha Zhang, Miao Gong, Jianhua Wu, Juntao Lu, Wei Guo, Zhaoxu Zheng, Zhanjun Guo
Cancer Biology & Medicine Jul 2026, 20250687; DOI: 10.20892/j.issn.2095-3941.2025.0687

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Apatinib enhances targeted immunotherapy via the IL-6-gp130-PI3K pathway in HER2-positive gastric cancer
Ruoxi Tian, Ziyue Sha, Shasha Zhang, Miao Gong, Jianhua Wu, Juntao Lu, Wei Guo, Zhaoxu Zheng, Zhanjun Guo
Cancer Biology & Medicine Jul 2026, 20250687; DOI: 10.20892/j.issn.2095-3941.2025.0687
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Keywords

  • HER2
  • gastric cancer
  • apatinib
  • trastuzumab
  • targeted immunotherapy

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