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Research ArticleOriginal Article
Open Access

FDX1 expression promotes DSF/Cu-induced cuproptosis in gastric cancer cells

Qirong Li, Yi Guo, Jiahuan Yuan, Qiang Feng, Hengzong Zhou, Ming Hao, Boqiang Tao, Liqun Sun, Chao Lin, Jianfeng Mu, Gongliang Guo and Dongxu Wang
Cancer Biology & Medicine July 2026, 20250323; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0323
Qirong Li
1Laboratory Animal Center, College of Animal Science, Jilin University, Changchun 130000, China
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Yi Guo
2The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130000, China
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Jiahuan Yuan
1Laboratory Animal Center, College of Animal Science, Jilin University, Changchun 130000, China
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Qiang Feng
1Laboratory Animal Center, College of Animal Science, Jilin University, Changchun 130000, China
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Hengzong Zhou
1Laboratory Animal Center, College of Animal Science, Jilin University, Changchun 130000, China
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Ming Hao
3Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Jilin University, Changchun 130000, China
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Boqiang Tao
3Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Jilin University, Changchun 130000, China
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Liqun Sun
4Outpatient Department of Pediatrics, Children’s Medical Center, The First Hospital of Jilin University, Changchun 130000, China
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Chao Lin
5Animal Science Department, School of Grain Engineering and Nutritional Science, Jilin Business and Technology College, Changchun 130000, China
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Jianfeng Mu
6Department of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130000, China
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Gongliang Guo
7Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun 130000, China
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  • For correspondence: docg{at}jlu.edu.cn wang_dong_xu{at}jlu.edu.cn
Dongxu Wang
1Laboratory Animal Center, College of Animal Science, Jilin University, Changchun 130000, China
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  • ORCID record for Dongxu Wang
  • For correspondence: docg{at}jlu.edu.cn wang_dong_xu{at}jlu.edu.cn
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Article Information

20250323
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2025.0323

Published By 
Cancer Biology & Medicine
History 
  • Received July 9, 2025
  • Accepted June 2, 2026
  • Published online July 28, 2026.

Copyright & Usage 
Copyright: © 2026, The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Author Information

  1. Qirong Li1,
  2. Yi Guo2,
  3. Jiahuan Yuan1,
  4. Qiang Feng1,
  5. Hengzong Zhou1,
  6. Ming Hao3,
  7. Boqiang Tao3,
  8. Liqun Sun4,
  9. Chao Lin5,
  10. Jianfeng Mu6,
  11. Gongliang Guo7⇑ and
  12. Dongxu Wang1⇑
  1. 1Laboratory Animal Center, College of Animal Science, Jilin University, Changchun 130000, China
  2. 2The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130000, China
  3. 3Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Jilin University, Changchun 130000, China
  4. 4Outpatient Department of Pediatrics, Children’s Medical Center, The First Hospital of Jilin University, Changchun 130000, China
  5. 5Animal Science Department, School of Grain Engineering and Nutritional Science, Jilin Business and Technology College, Changchun 130000, China
  6. 6Department of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130000, China
  7. 7Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun 130000, China
  1. Correspondence to: Gongliang Guo and Dongxu Wang, E-mail: docg{at}jlu.edu.cn and wang_dong_xu{at}jlu.edu.cn
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Funding

  • Jilin Province Science and Technology Development Program

    YDZJ202201ZYTS069
  • Wenzhou Science & Technology Bureau Basic Public Welfare Research Program

    Y20240006
  • Jilin University Young Teachers and Students Cross-disciplinary Training

    2023-JCXK-08

This work was supported by the Jilin Province Science and Technology Development Program under Grant YDZJ202201ZYTS069, the Wenzhou Science & Technology Bureau Basic Public Welfare Research Program under Grant Y20240006, and the Jilin University Young Teachers and Students Cross-disciplinary Training Project under Grant 2023-JCXK-08.

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Cancer Biology & Medicine: 23 (7)
Cancer Biology & Medicine
Vol. 23, Issue 7
15 Jul 2026
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FDX1 expression promotes DSF/Cu-induced cuproptosis in gastric cancer cells
Qirong Li, Yi Guo, Jiahuan Yuan, Qiang Feng, Hengzong Zhou, Ming Hao, Boqiang Tao, Liqun Sun, Chao Lin, Jianfeng Mu, Gongliang Guo, Dongxu Wang
Cancer Biology & Medicine Jul 2026, 20250323; DOI: 10.20892/j.issn.2095-3941.2025.0323

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FDX1 expression promotes DSF/Cu-induced cuproptosis in gastric cancer cells
Qirong Li, Yi Guo, Jiahuan Yuan, Qiang Feng, Hengzong Zhou, Ming Hao, Boqiang Tao, Liqun Sun, Chao Lin, Jianfeng Mu, Gongliang Guo, Dongxu Wang
Cancer Biology & Medicine Jul 2026, 20250323; DOI: 10.20892/j.issn.2095-3941.2025.0323
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Keywords

  • Cuproptosis
  • gastric cancer
  • DSF/Cu
  • NK cell exosomes
  • FDX1

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