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Research ArticleOriginal Article
Open Access

Myeloid cell reprogramming combined with zoledronic acid effectively suppresses bone metastasis

Yuting Luo, Yiran Cai, Zizheng Jiang, Ke Zheng, Shiji Ren, Lixia Yu, Baorui Liu, Tao Shi and Jia Wei
Cancer Biology & Medicine July 2026, 20260168; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0168
Yuting Luo
Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
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Yiran Cai
Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
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Zizheng Jiang
Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
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Ke Zheng
Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
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Shiji Ren
Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
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Lixia Yu
Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
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Baorui Liu
Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
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Tao Shi
Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
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  • ORCID record for Tao Shi
  • For correspondence: taoshi{at}smail.nju.edu.cn jiawei99{at}nju.edu.cn
Jia Wei
Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
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  • ORCID record for Jia Wei
  • For correspondence: taoshi{at}smail.nju.edu.cn jiawei99{at}nju.edu.cn
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Article Information

20260168
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2026.0168

Published By 
Cancer Biology & Medicine
History 
  • Received February 25, 2026
  • Accepted June 3, 2026
  • Published online July 27, 2026.

Copyright & Usage 
Copyright: © 2026, The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Author Information

  1. Yuting Luo,
  2. Yiran Cai,
  3. Zizheng Jiang,
  4. Ke Zheng,
  5. Shiji Ren,
  6. Lixia Yu,
  7. Baorui Liu,
  8. Tao Shi⇑ and
  9. Jia Wei⇑
  1. Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
  1. Correspondence to: Tao Shi and Jia Wei, E-mail: taoshi{at}smail.nju.edu.cn and jiawei99{at}nju.edu.cn
View Full Text

Funding

  • National Major Projects for ‘Major New Drugs Innovation and Development’

    2025ZD1800302
  • Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China

    JYB2025XDXM501
  • National Natural Science Foundation of China

    82373263
  • National Natural Science Foundation of China

    82403835
  • China Postdoctoral Science Foundation

    2024M751405
  • Jiangsu Provincial Natural Science Foundation Youth Project

    BK20240247
  • Fundamental Research Funds for the Central Universities

    2026300385

This work was funded by grants from the National Major Projects for ‘Major New Drugs Innovation and Development’ (2025ZD1800302), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM501), the National Natural Science Foundation of China (82373263 and 82403835), the China Postdoctoral Science Foundation (2024M751405), the Jiangsu Provincial Natural Science Foundation Youth Project (BK20240247), and the Fundamental Research Funds for the Central Universities (2026300385). The funding sources had no role in the study design, data collection, data analysis, data interpretation, or writing of the manuscript.

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Cancer Biology & Medicine: 23 (7)
Cancer Biology & Medicine
Vol. 23, Issue 7
15 Jul 2026
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Myeloid cell reprogramming combined with zoledronic acid effectively suppresses bone metastasis
Yuting Luo, Yiran Cai, Zizheng Jiang, Ke Zheng, Shiji Ren, Lixia Yu, Baorui Liu, Tao Shi, Jia Wei
Cancer Biology & Medicine Jul 2026, 20260168; DOI: 10.20892/j.issn.2095-3941.2026.0168

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Myeloid cell reprogramming combined with zoledronic acid effectively suppresses bone metastasis
Yuting Luo, Yiran Cai, Zizheng Jiang, Ke Zheng, Shiji Ren, Lixia Yu, Baorui Liu, Tao Shi, Jia Wei
Cancer Biology & Medicine Jul 2026, 20260168; DOI: 10.20892/j.issn.2095-3941.2026.0168
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Keywords

  • Bone metastasis
  • myeloid cell reprogramming
  • DKK1-CKAP4 axis
  • zoledronic acid
  • combination cancer therapy

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