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Genetic susceptibility, environmental risk factors, and incident gastric cancer risk among individuals with different Helicobacter pylori infection status: a population-based study

Hengmin Xu, Hui Ma, Yuxin Wang, Xinling Wang, Xuan Han, Wenjing Zhao, Yang Zhang, Tong Zhou, Jingying Zhang, Weicheng You, Wenqing Li and Kaifeng Pan
Cancer Biology & Medicine July 2026, 20260145; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0145
Hengmin Xu
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China
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Hui Ma
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China
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Yuxin Wang
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China
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Xinling Wang
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China
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Xuan Han
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China
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Wenjing Zhao
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China
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Yang Zhang
2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China
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Tong Zhou
2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China
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Jingying Zhang
2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China
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Weicheng You
2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China
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Wenqing Li
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China
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  • ORCID record for Wenqing Li
  • For correspondence: wenqing_li{at}bjmu.edu.cn pan-kf{at}263.net
Kaifeng Pan
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China
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  • For correspondence: wenqing_li{at}bjmu.edu.cn pan-kf{at}263.net
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Article Information

20260145
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2026.0145

Published By 
Cancer Biology & Medicine
History 
  • Received February 13, 2026
  • Accepted May 11, 2026
  • Published online July 14, 2026.

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  • You are currently viewing a previous version of this article (July 14, 2026 - 04:30).
  • View the most recent version of this article
Copyright & Usage 
Copyright: © 2026, The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Author Information

Funding

  • Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support

    ZLRK202325
  • Noncommunicable Chronic Diseases-National Science and Technology Major Project

    2023ZD0501400
  • Noncommunicable Chronic Diseases-National Science and Technology Major Project

    2025ZD0545200
  • Capital’s Funds for Health Improvement and Research

    2026-1Q-1091
  • National Natural Science Foundation of China

    82172555
  • National Natural Science Foundation of China

    82273704
  • National Natural Science Foundation of China

    82504482
  • Beijing Hospitals Authority’s Ascent Plan

    DFL20241102
  • China Postdoctoral Science Foundation

    2024M760152
  • Postdoctoral Fellowship Program of CPSF

    GZB20250192
  • Peking University Medicine Fund for World’s Leading Discipline or Discipline Cluster Development

    BMU2022XKQ004
  • Science Foundation of Peking University Cancer Hospital

    BJCH2024BJ02
  • Science Foundation of Peking University Cancer Hospital

    XKFZ2410
  • Science Foundation of Peking University Cancer Hospital

    BJCH2025CZ04

This study was funded by Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support (No. ZLRK202325), the Noncommunicable Chronic Diseases-National Science and Technology Major Project (Nos. 2023ZD0501400, 2025ZD0545200), Capital’s Funds for Health Improvement and Research (No. 2026-1Q-1091), National Natural Science Foundation of China (Nos. 82172555, 82273704, and 82504482), Beijing Hospitals Authority’s Ascent Plan (DFL20241102), China Postdoctoral Science Foundation (2024M760152), Postdoctoral Fellowship Program of CPSF (GZB20250192), Peking University Medicine Fund for World’s Leading Discipline or Discipline Cluster Development (No. BMU2022XKQ004), and Science Foundation of Peking University Cancer Hospital (Nos. BJCH2024BJ02, XKFZ2410, and BJCH2025CZ04).

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Cancer Biology & Medicine: 23 (8)
Cancer Biology & Medicine
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15 Aug 2026
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Genetic susceptibility, environmental risk factors, and incident gastric cancer risk among individuals with different Helicobacter pylori infection status: a population-based study
Hengmin Xu, Hui Ma, Yuxin Wang, Xinling Wang, Xuan Han, Wenjing Zhao, Yang Zhang, Tong Zhou, Jingying Zhang, Weicheng You, Wenqing Li, Kaifeng Pan
Cancer Biology & Medicine Jul 2026, 20260145; DOI: 10.20892/j.issn.2095-3941.2026.0145

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Genetic susceptibility, environmental risk factors, and incident gastric cancer risk among individuals with different Helicobacter pylori infection status: a population-based study
Hengmin Xu, Hui Ma, Yuxin Wang, Xinling Wang, Xuan Han, Wenjing Zhao, Yang Zhang, Tong Zhou, Jingying Zhang, Weicheng You, Wenqing Li, Kaifeng Pan
Cancer Biology & Medicine Jul 2026, 20260145; DOI: 10.20892/j.issn.2095-3941.2026.0145
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