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Open Access

The conditional promise of dual-epitope HER2 antibody-drug conjugates in breast cancer

Ruoqing Wang, Shuhao Jiang, Qun Zhang and Junjie Li
Cancer Biology & Medicine July 2026, 20260277; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0277
Ruoqing Wang
1Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai 200032, China
2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
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Shuhao Jiang
1Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai 200032, China
2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
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Qun Zhang
1Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai 200032, China
2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
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Junjie Li
1Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai 200032, China
2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
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  • For correspondence: lijunjie_ronaldo{at}hotmail.com
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Article Information

20260277
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2026.0277

Published By 
Cancer Biology & Medicine
History 
  • Received April 3, 2026
  • Accepted June 9, 2026
  • Published online July 13, 2026.

Copyright & Usage 
Copyright: © 2026, The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Author Information

Funding

  • National Natural Science Foundation of China

    82172576

This work was supported by the National Natural Science Foundation of China (Grant No. 82172576).

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Cancer Biology & Medicine: 23 (8)
Cancer Biology & Medicine
Vol. 23, Issue 8
15 Aug 2026
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The conditional promise of dual-epitope HER2 antibody-drug conjugates in breast cancer
Ruoqing Wang, Shuhao Jiang, Qun Zhang, Junjie Li
Cancer Biology & Medicine Jul 2026, 20260277; DOI: 10.20892/j.issn.2095-3941.2026.0277

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The conditional promise of dual-epitope HER2 antibody-drug conjugates in breast cancer
Ruoqing Wang, Shuhao Jiang, Qun Zhang, Junjie Li
Cancer Biology & Medicine Jul 2026, 20260277; DOI: 10.20892/j.issn.2095-3941.2026.0277
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    • Mechanistic rationale: the promise and limits of dual-epitope engagement
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