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LetterLetter
Open Access

Vitamin D potentiates STING agonist-induced antitumor immunity in NSCLC

Ke Li, Guichao Liu, Wenhui Yuan, Xinhai Zhu and Peng Li
Cancer Biology & Medicine July 2026, 20260211; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0211
Ke Li
1Institute of Cell and Gene Technology, Shenzhen University of Advanced Technology, Shenzhen 518107, China
2Department of Geriatrics, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China
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Guichao Liu
3Department of Radiation Oncology, The First People’s Hospital (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Foshan 528000, China
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Wenhui Yuan
4The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou 510632, China
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Xinhai Zhu
5Department of Oncology, The First Affiliated Hospital, Jinan University, Guangzhou 510632, China
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Peng Li
1Institute of Cell and Gene Technology, Shenzhen University of Advanced Technology, Shenzhen 518107, China
4The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou 510632, China
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  • ORCID record for Peng Li
  • For correspondence: pengli1991{at}jnu.edu.cn
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Article Information

20260211
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2026.0211

Published By 
Cancer Biology & Medicine
History 
  • Received March 16, 2026
  • Accepted June 5, 2026
  • Published online July 13, 2026.

Copyright & Usage 
Copyright: © 2026, The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Author Information

Funding

  • National Natural Science Foundation of China

    32300728
  • National Natural Science Foundation of China

    32541040
  • Guangdong Basic and Applied Basic Research Foundation

    2022A1515110416
  • Guangdong Basic and Applied Basic Research Foundation

    2024A1515140180
  • Guangdong Basic and Applied Basic Research Foundation

    2025A1515012241
  • Shenzhen Science and Technology Program

    JCYJ20240813150420027
  • Medical Scientific Research Foundation of Guangdong Province

    A2024713

This work was supported by the National Natural Science Foundation of China (Grant Nos. 32300728 and 32541040), the Guangdong Basic and Applied Basic Research Foundation (Grant Nos. 2022A1515110416, 2024A1515140180, and 2025A1515012241), the Shenzhen Science and Technology Program (Grant No. JCYJ20240813150420027), and the Medical Scientific Research Foundation of Guangdong Province (Grant No. A2024713).

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Cancer Biology & Medicine: 23 (8)
Cancer Biology & Medicine
Vol. 23, Issue 8
15 Aug 2026
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Vitamin D potentiates STING agonist-induced antitumor immunity in NSCLC
Ke Li, Guichao Liu, Wenhui Yuan, Xinhai Zhu, Peng Li
Cancer Biology & Medicine Jul 2026, 20260211; DOI: 10.20892/j.issn.2095-3941.2026.0211

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Vitamin D potentiates STING agonist-induced antitumor immunity in NSCLC
Ke Li, Guichao Liu, Wenhui Yuan, Xinhai Zhu, Peng Li
Cancer Biology & Medicine Jul 2026, 20260211; DOI: 10.20892/j.issn.2095-3941.2026.0211
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    • Vitamin D potentiates STING-mediated antitumor immunity through CD8+ T cells
    • Vitamin D enhances T cell receptor signaling and alleviates exhaustion in CD8+ T cells
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