LetterLetter
Open Access
A foundation model-enhanced CT radiomics signature for the noninvasive assessment of tertiary lymphoid structures and prediction of therapy benefit in gastric cancer
Xianchun Gao, Zhe Li, Jun Yu, Jiangpeng Wei, Didi Wen, Ning Han, Linbin Lu, Yongxi Song, Qiong Xiao, Guangtao Wu, Kun Feng, Shibo Wang, Zhongyang Zhang, Dai Zhang, Ling Chen, Zengshan Li, Minwen Zheng, Yong Xia and Yongzhan Nie
Cancer Biology & Medicine April 2026, 20260076; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0076
Xianchun Gao
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
Zhe Li
2School of Computer Science and Engineering, Northwestern Polytechnical University, Xi’an 710068, China
Jun Yu
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
Jiangpeng Wei
3Department of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
Didi Wen
4Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
Ning Han
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
Linbin Lu
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
Yongxi Song
5Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of Education, Shenyang 110100, China
Qiong Xiao
5Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of Education, Shenyang 110100, China
Guangtao Wu
5Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of Education, Shenyang 110100, China
Kun Feng
5Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of Education, Shenyang 110100, China
Shibo Wang
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
Zhongyang Zhang
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
Dai Zhang
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
Ling Chen
6State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, China
Zengshan Li
6State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, China
Minwen Zheng
4Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
Yong Xia
2School of Computer Science and Engineering, Northwestern Polytechnical University, Xi’an 710068, China
Yongzhan Nie
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China

References
- 1.↵
- 2.
- 3.↵
- 4.↵
- 5.
- Li Z,
- Jiang Y,
- Li B,
- Han Z,
- Shen J,
- Xia Y, et al.
- 6.↵
- 7.↵
- 8.↵
- 9.↵
- 10.↵
- Su JY,
- Li JR,
- Pan LX,
- Ma YL,
- Tian W,
- Jiang YM, et al.
In this issue
A foundation model-enhanced CT radiomics signature for the noninvasive assessment of tertiary lymphoid structures and prediction of therapy benefit in gastric cancer
Xianchun Gao, Zhe Li, Jun Yu, Jiangpeng Wei, Didi Wen, Ning Han, Linbin Lu, Yongxi Song, Qiong Xiao, Guangtao Wu, Kun Feng, Shibo Wang, Zhongyang Zhang, Dai Zhang, Ling Chen, Zengshan Li, Minwen Zheng, Yong Xia, Yongzhan Nie
Cancer Biology & Medicine Apr 2026, 20260076; DOI: 10.20892/j.issn.2095-3941.2026.0076
A foundation model-enhanced CT radiomics signature for the noninvasive assessment of tertiary lymphoid structures and prediction of therapy benefit in gastric cancer
Xianchun Gao, Zhe Li, Jun Yu, Jiangpeng Wei, Didi Wen, Ning Han, Linbin Lu, Yongxi Song, Qiong Xiao, Guangtao Wu, Kun Feng, Shibo Wang, Zhongyang Zhang, Dai Zhang, Ling Chen, Zengshan Li, Minwen Zheng, Yong Xia, Yongzhan Nie
Cancer Biology & Medicine Apr 2026, 20260076; DOI: 10.20892/j.issn.2095-3941.2026.0076
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