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LetterLetter
Open Access

A foundation model-enhanced CT radiomics signature for the noninvasive assessment of tertiary lymphoid structures and prediction of therapy benefit in gastric cancer

Xianchun Gao, Zhe Li, Jun Yu, Jiangpeng Wei, Didi Wen, Ning Han, Linbin Lu, Yongxi Song, Qiong Xiao, Guangtao Wu, Kun Feng, Shibo Wang, Zhongyang Zhang, Dai Zhang, Ling Chen, Zengshan Li, Minwen Zheng, Yong Xia and Yongzhan Nie
Cancer Biology & Medicine April 2026, 20260076; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0076
Xianchun Gao
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
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Zhe Li
2School of Computer Science and Engineering, Northwestern Polytechnical University, Xi’an 710068, China
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Jun Yu
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
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Jiangpeng Wei
3Department of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
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Didi Wen
4Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
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Ning Han
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
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Linbin Lu
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
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Yongxi Song
5Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of Education, Shenyang 110100, China
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Qiong Xiao
5Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of Education, Shenyang 110100, China
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Guangtao Wu
5Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of Education, Shenyang 110100, China
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Kun Feng
5Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of Education, Shenyang 110100, China
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Shibo Wang
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
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Zhongyang Zhang
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
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Dai Zhang
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
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Ling Chen
6State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, China
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Zengshan Li
6State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, China
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Minwen Zheng
4Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
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  • For correspondence: zhengmw2007{at}163.com yxia{at}nwpu.edu.cn yongznie{at}fmmu.edu.cn
Yong Xia
2School of Computer Science and Engineering, Northwestern Polytechnical University, Xi’an 710068, China
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  • For correspondence: zhengmw2007{at}163.com yxia{at}nwpu.edu.cn yongznie{at}fmmu.edu.cn
Yongzhan Nie
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
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  • ORCID record for Yongzhan Nie
  • For correspondence: zhengmw2007{at}163.com yxia{at}nwpu.edu.cn yongznie{at}fmmu.edu.cn
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Article Information

20260076
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2026.0076

Published By 
Cancer Biology & Medicine
History 
  • Received January 26, 2026
  • Accepted March 6, 2026
  • Published online April 16, 2026.

Copyright & Usage 
Copyright: © 2026, The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Author Information

Funding

  • National Natural Science Foundation of China

    82202837
  • Noncommunicable Chronic Diseases-National Science and Technology Major Project

    2025ZD0545200
  • Noncommunicable Chronic Diseases-National Science and Technology Major Project

    2023ZD0501400
  • National Natural Science Foundation of China

    82421002
  • National Natural Science Foundation of China

    82350122
  • National Key R&D Program of China

    2022YFC2505100
  • Postdoctoral Fellowship Program of CPSF

    GZC20242251
  • China Postdoctoral Science Foundation

    2024M754223

This work was supported by the National Natural Science Foundation of China (Grant No. 82202837), the Noncommunicable Chronic Diseases-National Science and Technology Major Project (Grant Nos. 2025ZD0545200, and 2023ZD0501400), the National Natural Science Foundation of China (Grant Nos. 82421002 and 82350122), the National Key R&D Program of China (Grant No. 2022YFC2505100), the Postdoctoral Fellowship Program of CPSF (Grant No. GZC20242251), and the China Postdoctoral Science Foundation (Grant No. 2024M754223).

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Cancer Biology & Medicine: 23 (5)
Cancer Biology & Medicine
Vol. 23, Issue 5
15 May 2026
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A foundation model-enhanced CT radiomics signature for the noninvasive assessment of tertiary lymphoid structures and prediction of therapy benefit in gastric cancer
Xianchun Gao, Zhe Li, Jun Yu, Jiangpeng Wei, Didi Wen, Ning Han, Linbin Lu, Yongxi Song, Qiong Xiao, Guangtao Wu, Kun Feng, Shibo Wang, Zhongyang Zhang, Dai Zhang, Ling Chen, Zengshan Li, Minwen Zheng, Yong Xia, Yongzhan Nie
Cancer Biology & Medicine Apr 2026, 20260076; DOI: 10.20892/j.issn.2095-3941.2026.0076

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A foundation model-enhanced CT radiomics signature for the noninvasive assessment of tertiary lymphoid structures and prediction of therapy benefit in gastric cancer
Xianchun Gao, Zhe Li, Jun Yu, Jiangpeng Wei, Didi Wen, Ning Han, Linbin Lu, Yongxi Song, Qiong Xiao, Guangtao Wu, Kun Feng, Shibo Wang, Zhongyang Zhang, Dai Zhang, Ling Chen, Zengshan Li, Minwen Zheng, Yong Xia, Yongzhan Nie
Cancer Biology & Medicine Apr 2026, 20260076; DOI: 10.20892/j.issn.2095-3941.2026.0076
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