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LetterLetter
Open Access

Sequential nimotuzumab plus gemcitabine and nab-paclitaxel chemotherapy followed by irreversible electroporation in advanced pancreatic ductal adenocarcinoma: a retrospective real-world analysis

Yang Liu, Dandan Wu, Xing Li, Xihao Zhang, Rentao Li, Yanmei Ou, Hao Wang, Tongguo Si, Rui Xia, Yong Xu, Huikai Li, Chuntao Gao and Jihui Hao
Cancer Biology & Medicine March 2026, 20250848; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0848
Yang Liu
1Department of Hepatobiliary Cancer, Liver Cancer Center, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
2Department of Hepatobiliary and Pancreatic Oncology, Tianjin Cancer Hospital Airport Hospital, National Clinical Research Center for Cancer, Tianjin 300308, China
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Dandan Wu
1Department of Hepatobiliary Cancer, Liver Cancer Center, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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Xing Li
3Department of Ultrasound Diagnosis and Treatment, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
4Department of Ultrasound Diagnosis and Treatment, Tianjin Cancer Hospital Airport Hospital, National Clinical Research Center for Cancer, Tianjin 300308, China
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Xihao Zhang
2Department of Hepatobiliary and Pancreatic Oncology, Tianjin Cancer Hospital Airport Hospital, National Clinical Research Center for Cancer, Tianjin 300308, China
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Rentao Li
2Department of Hepatobiliary and Pancreatic Oncology, Tianjin Cancer Hospital Airport Hospital, National Clinical Research Center for Cancer, Tianjin 300308, China
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Yanmei Ou
4Department of Ultrasound Diagnosis and Treatment, Tianjin Cancer Hospital Airport Hospital, National Clinical Research Center for Cancer, Tianjin 300308, China
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Hao Wang
1Department of Hepatobiliary Cancer, Liver Cancer Center, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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Tongguo Si
5Department of Interventional Therapy, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
6Department of Interventional Therapy, Tianjin Cancer Hospital Airport Hospital, National Clinical Research Center for Cancer, Tianjin 300308, China
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Rui Xia
7Intensive Care Unit, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
8Intensive Care Unit, Tianjin Cancer Hospital Airport Hospital, National Clinical Research Center for Cancer, Tianjin 300308, China
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Yong Xu
3Department of Ultrasound Diagnosis and Treatment, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
4Department of Ultrasound Diagnosis and Treatment, Tianjin Cancer Hospital Airport Hospital, National Clinical Research Center for Cancer, Tianjin 300308, China
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Huikai Li
1Department of Hepatobiliary Cancer, Liver Cancer Center, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
2Department of Hepatobiliary and Pancreatic Oncology, Tianjin Cancer Hospital Airport Hospital, National Clinical Research Center for Cancer, Tianjin 300308, China
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  • For correspondence: tjchlhk{at}tmu.edu.cn gaochuntao{at}tjmuch.com haojihui{at}tjmuch.com
Chuntao Gao
2Department of Hepatobiliary and Pancreatic Oncology, Tianjin Cancer Hospital Airport Hospital, National Clinical Research Center for Cancer, Tianjin 300308, China
9Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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  • For correspondence: tjchlhk{at}tmu.edu.cn gaochuntao{at}tjmuch.com haojihui{at}tjmuch.com
Jihui Hao
2Department of Hepatobiliary and Pancreatic Oncology, Tianjin Cancer Hospital Airport Hospital, National Clinical Research Center for Cancer, Tianjin 300308, China
9Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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  • For correspondence: tjchlhk{at}tmu.edu.cn gaochuntao{at}tjmuch.com haojihui{at}tjmuch.com
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Article Information

20250848
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2025.0848

Published By 
Cancer Biology & Medicine
History 
  • Received January 13, 2026
  • Accepted February 25, 2026
  • Published online March 24, 2026.

Article Versions

  • previous version (March 16, 2026 - 02:02).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright: © 2026, The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Author Information

Funding

  • Tianjin Health Science and Technology Project

    TJWJ2022MS007
  • Science & Technology Development Fund of Tianjin Education Commission for Higher Education

    2022ZD067
  • Tianjin Municipal Science and Technology Bureau

    22ZXJBSY00030
  • National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine

    24ZXZSSS00440
  • Independent Project of the Key Laboratory of Drug Efficacy Evaluation and Systematic Translational Medicine, Tianjin Medical University Cancer Institute and Hospital

    QZ23-11

This study received support from Tianjin Health Science and Technology Project (Grant No. TJWJ2022MS007), the Science & Technology Development Fund of Tianjin Education Commission for Higher Education (Grant No. 2022ZD067), the Tianjin Municipal Science and Technology Bureau (Grant No. 22ZXJBSY00030), the National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine (Grant No. 24ZXZSSS00440), and the Independent Project of the Key Laboratory of Drug Efficacy Evaluation and Systematic Translational Medicine, Tianjin Medical University Cancer Institute and Hospital (Grant No. QZ23-11).

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Cancer Biology & Medicine: 23 (4)
Cancer Biology & Medicine
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Sequential nimotuzumab plus gemcitabine and nab-paclitaxel chemotherapy followed by irreversible electroporation in advanced pancreatic ductal adenocarcinoma: a retrospective real-world analysis
Yang Liu, Dandan Wu, Xing Li, Xihao Zhang, Rentao Li, Yanmei Ou, Hao Wang, Tongguo Si, Rui Xia, Yong Xu, Huikai Li, Chuntao Gao, Jihui Hao
Cancer Biology & Medicine Mar 2026, 20250848; DOI: 10.20892/j.issn.2095-3941.2025.0848

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Sequential nimotuzumab plus gemcitabine and nab-paclitaxel chemotherapy followed by irreversible electroporation in advanced pancreatic ductal adenocarcinoma: a retrospective real-world analysis
Yang Liu, Dandan Wu, Xing Li, Xihao Zhang, Rentao Li, Yanmei Ou, Hao Wang, Tongguo Si, Rui Xia, Yong Xu, Huikai Li, Chuntao Gao, Jihui Hao
Cancer Biology & Medicine Mar 2026, 20250848; DOI: 10.20892/j.issn.2095-3941.2025.0848
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