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LetterLetter
Open Access

Enhancing FIT-based colorectal cancer screening through risk prediction: a comparative evaluation of 17 models in a large Chinese cohort

Le Wang, Weimiao Wu, Bin Liu, Chen Zhu, Yumeng Ding, Yi Zhou, Weiwei Chen, Lijuan Dai, Xueni Chen, Yuefan Shen, Tingting Pan, Xiaohui Sun, Huizhang Li, Dong Hang, Yingying Mao, Partha Basu and Lingbin Du
Cancer Biology & Medicine March 2026, 20250702; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0702
Le Wang
1Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China
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Weimiao Wu
1Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China
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Bin Liu
1Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China
2Department of Epidemiology, School of Public Health, Zhejiang Chinese Medical University, Hangzhou 310053, China
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Chen Zhu
1Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China
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Yumeng Ding
1Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China
3Department of Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing 211166, China
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Yi Zhou
1Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China
2Department of Epidemiology, School of Public Health, Zhejiang Chinese Medical University, Hangzhou 310053, China
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Weiwei Chen
3Department of Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing 211166, China
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Lijuan Dai
3Department of Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing 211166, China
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Xueni Chen
3Department of Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing 211166, China
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Yuefan Shen
3Department of Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing 211166, China
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Tingting Pan
1Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China
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Xiaohui Sun
2Department of Epidemiology, School of Public Health, Zhejiang Chinese Medical University, Hangzhou 310053, China
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Huizhang Li
1Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China
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Dong Hang
3Department of Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing 211166, China
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Yingying Mao
2Department of Epidemiology, School of Public Health, Zhejiang Chinese Medical University, Hangzhou 310053, China
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  • ORCID record for Yingying Mao
  • For correspondence: myy{at}zcmu.edu.cn basup{at}iarc.who.int dulb{at}zjcc.org.cn
Partha Basu
4Early Detection, Prevention & Infections Branch, International Agency for Research on Cancer (WHO), Lyon 69007, France
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  • For correspondence: myy{at}zcmu.edu.cn basup{at}iarc.who.int dulb{at}zjcc.org.cn
Lingbin Du
1Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China
5Zhejiang Key Laboratory of Prevention, Diagnosis and Therapy for Gastrointestinal Cancer, Hangzhou 310022, China
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  • For correspondence: myy{at}zcmu.edu.cn basup{at}iarc.who.int dulb{at}zjcc.org.cn
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Cancer Biology & Medicine: 23 (5)
Cancer Biology & Medicine
Vol. 23, Issue 5
15 May 2026
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Enhancing FIT-based colorectal cancer screening through risk prediction: a comparative evaluation of 17 models in a large Chinese cohort
Le Wang, Weimiao Wu, Bin Liu, Chen Zhu, Yumeng Ding, Yi Zhou, Weiwei Chen, Lijuan Dai, Xueni Chen, Yuefan Shen, Tingting Pan, Xiaohui Sun, Huizhang Li, Dong Hang, Yingying Mao, Partha Basu, Lingbin Du
Cancer Biology & Medicine Mar 2026, 20250702; DOI: 10.20892/j.issn.2095-3941.2025.0702

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Enhancing FIT-based colorectal cancer screening through risk prediction: a comparative evaluation of 17 models in a large Chinese cohort
Le Wang, Weimiao Wu, Bin Liu, Chen Zhu, Yumeng Ding, Yi Zhou, Weiwei Chen, Lijuan Dai, Xueni Chen, Yuefan Shen, Tingting Pan, Xiaohui Sun, Huizhang Li, Dong Hang, Yingying Mao, Partha Basu, Lingbin Du
Cancer Biology & Medicine Mar 2026, 20250702; DOI: 10.20892/j.issn.2095-3941.2025.0702
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  • Article
    • Overall study design and analytical framework
    • Identification and characteristics of colorectal cancer risk prediction models
    • Discrimination and calibration performance of risk prediction models in external validation
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