Enhancing FIT-based colorectal cancer screening through risk prediction: a comparative evaluation of 17 models in a large Chinese cohort

Le Wang; Weimiao Wu; Bin Liu; Chen Zhu; Yumeng Ding; Yi Zhou; Weiwei Chen; Lijuan Dai; Xueni Chen; Yuefan Shen; Tingting Pan; Xiaohui Sun; Huizhang Li; Dong Hang; Yingying Mao; Partha Basu; Lingbin Du

doi:10.20892/j.issn.2095-3941.2025.0702

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Enhancing FIT-based colorectal cancer screening through risk prediction: a comparative evaluation of 17 models in a large Chinese cohort

Le Wang, Weimiao Wu, Bin Liu, Chen Zhu, Yumeng Ding, Yi Zhou, Weiwei Chen, Lijuan Dai, Xueni Chen, Yuefan Shen, Tingting Pan, Xiaohui Sun, Huizhang Li, Dong Hang, Yingying Mao, Partha Basu and Lingbin Du

Cancer Biology & Medicine March 2026, 20250702; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0702

Le Wang

1Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China

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Weimiao Wu

1Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China

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Bin Liu

1Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China

2Department of Epidemiology, School of Public Health, Zhejiang Chinese Medical University, Hangzhou 310053, China

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Chen Zhu

1Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China

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Yumeng Ding

1Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China

3Department of Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing 211166, China

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Yi Zhou

1Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China

2Department of Epidemiology, School of Public Health, Zhejiang Chinese Medical University, Hangzhou 310053, China

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Weiwei Chen

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Lijuan Dai

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Xueni Chen

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Yuefan Shen

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Tingting Pan

1Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China

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Xiaohui Sun

2Department of Epidemiology, School of Public Health, Zhejiang Chinese Medical University, Hangzhou 310053, China

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Huizhang Li

1Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China

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Dong Hang

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Yingying Mao

2Department of Epidemiology, School of Public Health, Zhejiang Chinese Medical University, Hangzhou 310053, China

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ORCID record for Yingying Mao
For correspondence: myy{at}zcmu.edu.cn basup{at}iarc.who.int dulb{at}zjcc.org.cn

Partha Basu

4Early Detection, Prevention & Infections Branch, International Agency for Research on Cancer (WHO), Lyon 69007, France

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For correspondence: myy{at}zcmu.edu.cn basup{at}iarc.who.int dulb{at}zjcc.org.cn

Lingbin Du

1Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China

5Zhejiang Key Laboratory of Prevention, Diagnosis and Therapy for Gastrointestinal Cancer, Hangzhou 310022, China

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ORCID record for Lingbin Du
For correspondence: myy{at}zcmu.edu.cn basup{at}iarc.who.int dulb{at}zjcc.org.cn

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20250702

DOI

https://doi.org/10.20892/j.issn.2095-3941.2025.0702

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Cancer Biology & Medicine

History

Received November 28, 2025
Accepted February 26, 2026
Published online March 24, 2026.

Author Information

Funding

Zhejiang Provincial Medical and Health Science and Technology Plan
2025KY677
Zhejiang Provincial Natural Science Foundation of China
LTGY23H260004
Zhejiang Provincial Natural Science Foundation of China
LQN25G030004
Noncommunicable Chronic Diseases-National Science and Technology Major Project
2024ZD0520100
Noncommunicable Chronic Diseases-National Science and Technology Major Project
2024ZD0520103
Postdoctoral Science Foundation of Zhejiang Province
ZJ2024074
Science and Technology Program for Disease Prevention and Control of Zhejiang Province
2025JK018

This study was supported by Zhejiang Provincial Medical and Health Science and Technology Plan (Grant No. 2025KY677); Zhejiang Provincial Natural Science Foundation of China (Grant Nos. LTGY23H260004 and LQN25G030004); Noncommunicable Chronic Diseases-National Science and Technology Major Project (Grant Nos. 2024ZD0520100 and 2024ZD0520103); Postdoctoral Science Foundation of Zhejiang Province (Grant No. ZJ2024074); Science and Technology Program for Disease Prevention and Control of Zhejiang Province (Grant No. 2025JK018); and the UICC Technical Fellowship and Zhejiang Key Laboratory of Prevention; Diagnosis and Therapy for Gastrointestinal Cancer.

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Enhancing FIT-based colorectal cancer screening through risk prediction: a comparative evaluation of 17 models in a large Chinese cohort

Cancer Biology & Medicine Mar 2026, 20250702; DOI: 10.20892/j.issn.2095-3941.2025.0702

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Enhancing FIT-based colorectal cancer screening through risk prediction: a comparative evaluation of 17 models in a large Chinese cohort

Cancer Biology & Medicine Mar 2026, 20250702; DOI: 10.20892/j.issn.2095-3941.2025.0702

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Enhancing FIT-based colorectal cancer screening through risk prediction: a comparative evaluation of 17 models in a large Chinese cohort

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Author Information

Funding

Zhejiang Provincial Medical and Health Science and Technology Plan

Zhejiang Provincial Natural Science Foundation of China

Zhejiang Provincial Natural Science Foundation of China

Noncommunicable Chronic Diseases-National Science and Technology Major Project

Noncommunicable Chronic Diseases-National Science and Technology Major Project

Postdoctoral Science Foundation of Zhejiang Province

Science and Technology Program for Disease Prevention and Control of Zhejiang Province

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