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Review ArticleReview
Open Access

Microbiota-host interaction in colorectal cancer: emerging computational technology, multi-omics integration, and mechanisms

Yinghong Lu and Jun Yu
Cancer Biology & Medicine February 2026, 20250762; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0762
Yinghong Lu
Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
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Jun Yu
Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
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  • ORCID record for Jun Yu
  • For correspondence: junyu{at}cuhk.edu.hk
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Article Information

20250762
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2025.0762

Published By 
Cancer Biology & Medicine
History 
  • Received November 28, 2025
  • Accepted January 12, 2026
  • Published online February 23, 2026.

Copyright & Usage 
Copyright: © 2026, The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Author Information

  1. Yinghong Lu and
  2. Jun Yu⇑
  1. Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
  1. Correspondence to: Jun Yu, E-mail: junyu{at}cuhk.edu.hk
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Funding

  • Noncommunicable Chronic Diseases-National Science and Technology Major Project

    2023ZD0500200
  • Strategic Seed Funding Collaboration Research Scheme CUHK

    3133344
  • Strategic Impact Enhancement Fund CUHK

    3135509
  • Impact Case for RAE CUHK

    3134277

This work was supported by the Noncommunicable Chronic Diseases-National Science and Technology Major Project (Grant No. 2023ZD0500200), the Strategic Seed Funding Collaboration Research Scheme CUHK (Grant No. 3133344), the Strategic Impact Enhancement Fund CUHK (Grant No. 3135509), and the Impact Case for RAE CUHK (Grant No. 3134277).

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Cancer Biology & Medicine: 23 (3)
Cancer Biology & Medicine
Vol. 23, Issue 3
15 Mar 2026
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Microbiota-host interaction in colorectal cancer: emerging computational technology, multi-omics integration, and mechanisms
Yinghong Lu, Jun Yu
Cancer Biology & Medicine Feb 2026, 20250762; DOI: 10.20892/j.issn.2095-3941.2025.0762

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Microbiota-host interaction in colorectal cancer: emerging computational technology, multi-omics integration, and mechanisms
Yinghong Lu, Jun Yu
Cancer Biology & Medicine Feb 2026, 20250762; DOI: 10.20892/j.issn.2095-3941.2025.0762
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  • Article
    • Abstract
    • Introduction
    • Microbiome and host interplay at multi-omics layers
    • Computational approaches for microbiome multi-omics integration
    • Challenges in microbiome multi-omics integration
    • Emerging technologies for studying host-microbiota interplay
    • Conclusions and future directions
    • Conflict of interest statement
    • Author contributions
    • References
  • Figures & Data
  • Info & Metrics
  • References
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Keywords

  • colorectal cancer
  • microbiota
  • high-throughput sequencing
  • multi-omics integration
  • bioinformatics

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