Research ArticleOriginal Article
Open Access
Exosomal EPHA2 transfers metastatic potential by stabilizing TGF-βRI and activating the TGF-β/SMAD3 signaling pathway in breast cancer
Liming Liu, Yichu Zhang, Xiaoxue Li, Yueni Mo, Lanlan Song, Yidi Jia, Luoming Zhang, Wei Zhou, He Zhang, Hui Guo, Zhiyong Wang, Yanfen Cui, Fei Zhang and Ruifang Niu
Cancer Biology & Medicine February 2026, 20250440; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0440
Liming Liu
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
Yichu Zhang
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
Xiaoxue Li
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
Yueni Mo
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
Lanlan Song
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
Yidi Jia
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
Luoming Zhang
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
Wei Zhou
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
He Zhang
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
Hui Guo
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
Zhiyong Wang
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
Yanfen Cui
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
Fei Zhang
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
Ruifang Niu
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China

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In this issue
Exosomal EPHA2 transfers metastatic potential by stabilizing TGF-βRI and activating the TGF-β/SMAD3 signaling pathway in breast cancer
Liming Liu, Yichu Zhang, Xiaoxue Li, Yueni Mo, Lanlan Song, Yidi Jia, Luoming Zhang, Wei Zhou, He Zhang, Hui Guo, Zhiyong Wang, Yanfen Cui, Fei Zhang, Ruifang Niu
Cancer Biology & Medicine Feb 2026, 20250440; DOI: 10.20892/j.issn.2095-3941.2025.0440
Exosomal EPHA2 transfers metastatic potential by stabilizing TGF-βRI and activating the TGF-β/SMAD3 signaling pathway in breast cancer
Liming Liu, Yichu Zhang, Xiaoxue Li, Yueni Mo, Lanlan Song, Yidi Jia, Luoming Zhang, Wei Zhou, He Zhang, Hui Guo, Zhiyong Wang, Yanfen Cui, Fei Zhang, Ruifang Niu
Cancer Biology & Medicine Feb 2026, 20250440; DOI: 10.20892/j.issn.2095-3941.2025.0440
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