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Research ArticleOriginal Article
Open Access

Exosomal EPHA2 transfers metastatic potential by stabilizing TGF-βRI and activating the TGF-β/SMAD3 signaling pathway in breast cancer

Liming Liu, Yichu Zhang, Xiaoxue Li, Yueni Mo, Lanlan Song, Yidi Jia, Luoming Zhang, Wei Zhou, He Zhang, Hui Guo, Zhiyong Wang, Yanfen Cui, Fei Zhang and Ruifang Niu
Cancer Biology & Medicine February 2026, 20250440; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0440
Liming Liu
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
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Yichu Zhang
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
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Xiaoxue Li
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
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Yueni Mo
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
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Lanlan Song
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
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Yidi Jia
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
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Luoming Zhang
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
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Wei Zhou
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
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He Zhang
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
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Hui Guo
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
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Zhiyong Wang
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
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Yanfen Cui
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
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Fei Zhang
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
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  • ORCID record for Fei Zhang
  • For correspondence: feizhang03{at}tmu.edu.cn rniu{at}tmu.edu.cn
Ruifang Niu
1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
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  • For correspondence: feizhang03{at}tmu.edu.cn rniu{at}tmu.edu.cn
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Article Information

20250440
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2025.0440

Published By 
Cancer Biology & Medicine
History 
  • Received August 12, 2025
  • Accepted December 15, 2025
  • Published online February 23, 2026.

Article Versions

  • You are currently viewing a previous version of this article (February 23, 2026 - 07:08).
  • View the most recent version of this article
Copyright & Usage 
Copyright: © 2026, The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Author Information

  1. Liming Liu1,2,3,
  2. Yichu Zhang1,2,3,
  3. Xiaoxue Li1,2,3,
  4. Yueni Mo1,2,3,
  5. Lanlan Song1,2,3,
  6. Yidi Jia1,2,3,
  7. Luoming Zhang1,2,3,
  8. Wei Zhou1,2,3,
  9. He Zhang1,2,3,
  10. Hui Guo1,2,3,
  11. Zhiyong Wang1,2,3,
  12. Yanfen Cui1,2,3,
  13. Fei Zhang1,2,3⇑ and
  14. Ruifang Niu1,2,3⇑
  1. 1Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
  2. 2Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
  3. 3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
  1. Correspondence to: Fei Zhang and Ruifang Niu, E-mail: feizhang03{at}tmu.edu.cn and rniu{at}tmu.edu.cn
View Full Text

Funding

  • National Natural Science Foundation of China

    82573172
  • National Natural Science Foundation of China

    82472996
  • National Natural Science Foundation of China

    82073085
  • National Natural Science Foundation of China

    82203687

This work was supported by grants from the National Natural Science Foundation of China (Grant Nos. 82573172, 82472996, 82073085, and 82203687).

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Cancer Biology & Medicine: 23 (8)
Cancer Biology & Medicine
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15 Aug 2026
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Exosomal EPHA2 transfers metastatic potential by stabilizing TGF-βRI and activating the TGF-β/SMAD3 signaling pathway in breast cancer
Liming Liu, Yichu Zhang, Xiaoxue Li, Yueni Mo, Lanlan Song, Yidi Jia, Luoming Zhang, Wei Zhou, He Zhang, Hui Guo, Zhiyong Wang, Yanfen Cui, Fei Zhang, Ruifang Niu
Cancer Biology & Medicine Feb 2026, 20250440; DOI: 10.20892/j.issn.2095-3941.2025.0440

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Exosomal EPHA2 transfers metastatic potential by stabilizing TGF-βRI and activating the TGF-β/SMAD3 signaling pathway in breast cancer
Liming Liu, Yichu Zhang, Xiaoxue Li, Yueni Mo, Lanlan Song, Yidi Jia, Luoming Zhang, Wei Zhou, He Zhang, Hui Guo, Zhiyong Wang, Yanfen Cui, Fei Zhang, Ruifang Niu
Cancer Biology & Medicine Feb 2026, 20250440; DOI: 10.20892/j.issn.2095-3941.2025.0440
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Keywords

  • Breast cancer
  • intratumor heterogeneity
  • exosomes
  • EPHA2
  • TGF-βRI

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