Rethinking anti-cancer drug discovery: the evolution from polypharmacy to unified drug units

Artificially intelligent synergistic engineered drugs as a novel anti-cancer therapeutic strategy. (A) A crucial aspect of the novel drug strategy AISED is the rational integration design of 3 primary linkage modalities: chemical conjugation form, physical assembly form, and co-delivery system form. (B) Additionally, the multiple ingredient combinations that make up AISED achieve therapeutic paradigms via multiple molecular targets and multiple biological effects, in multiple cancer types. (C) Through precise and rational design, new anti-cancer therapies will be transformed from a complex experience that relies on physicians to more predictable and controllable precision engineering, thus pioneering efficacy, safety, patient convenience, and medical strategy benefits among anti-cancer therapies.