Skip to main content

Main menu

  • Home
  • About
    • About CBM
    • Editorial Board
    • Announcement
  • Articles
    • Ahead of print
    • Current Issue
    • Archive
    • Collections
    • Cover Story
  • For Authors
    • Instructions for Authors
    • Resources
    • Submit a Manuscript
  • For Reviewers
    • Become a Reviewer
    • Instructions for Reviewers
    • Resources
    • Outstanding Reviewer
  • Subscription
  • Alerts
    • Email Alerts
    • RSS Feeds
    • Table of Contents
  • Contact us
  • Other Publications
    • cbm

User menu

  • My alerts

Search

  • Advanced search
Cancer Biology & Medicine
  • Other Publications
    • cbm
  • My alerts
Cancer Biology & Medicine

Advanced Search

 

  • Home
  • About
    • About CBM
    • Editorial Board
    • Announcement
  • Articles
    • Ahead of print
    • Current Issue
    • Archive
    • Collections
    • Cover Story
  • For Authors
    • Instructions for Authors
    • Resources
    • Submit a Manuscript
  • For Reviewers
    • Become a Reviewer
    • Instructions for Reviewers
    • Resources
    • Outstanding Reviewer
  • Subscription
  • Alerts
    • Email Alerts
    • RSS Feeds
    • Table of Contents
  • Contact us
  • Follow cbm on Twitter
  • Visit cbm on Facebook
Research ArticleOriginal Article
Open Access

Temporal radiomics for non-invasive preoperative prediction of pathologic complete response to neoadjuvant chemoimmunotherapy in non-small cell lung cancer

Sunyi Zheng, Shuo Wang, Ziwei Feng, Jing Liang, Jiaxin Liu, Xiaomeng Yang, Zhanshuo Zhang, Yuechen Cui, Jiping Xie, Shuxuan Fan, Jing Wang, Guoqing Liao, Haiyu Zhou, Zhaoxiang Ye, Jianyu Xiao, Lei Shi, Xiaonan Cui and Dongsheng Yue
Cancer Biology & Medicine January 2026, 20250327; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0327
Sunyi Zheng
1Department of Radiology, Medical Artificial General Intelligence for Computation (MAGIC) Lab, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shuo Wang
2Department of Lung Cancer, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ziwei Feng
3National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Molecular Cancer Epidemiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jing Liang
1Department of Radiology, Medical Artificial General Intelligence for Computation (MAGIC) Lab, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jiaxin Liu
1Department of Radiology, Medical Artificial General Intelligence for Computation (MAGIC) Lab, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xiaomeng Yang
1Department of Radiology, Medical Artificial General Intelligence for Computation (MAGIC) Lab, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zhanshuo Zhang
2Department of Lung Cancer, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yuechen Cui
2Department of Lung Cancer, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jiping Xie
2Department of Lung Cancer, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shuxuan Fan
1Department of Radiology, Medical Artificial General Intelligence for Computation (MAGIC) Lab, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jing Wang
4School of Public Health, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Guoqing Liao
5Department of Thoracic Surgery, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Haiyu Zhou
5Department of Thoracic Surgery, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zhaoxiang Ye
1Department of Radiology, Medical Artificial General Intelligence for Computation (MAGIC) Lab, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jianyu Xiao
1Department of Radiology, Medical Artificial General Intelligence for Computation (MAGIC) Lab, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lei Shi
6Department of Radiology, Zhejiang Cancer Hospital, Hangzhou 310022, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: yuedongsheng_cg{at}163.com cuixiaonan{at}tjmuch.com shilei{at}zjcc.org.cn
Xiaonan Cui
1Department of Radiology, Medical Artificial General Intelligence for Computation (MAGIC) Lab, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: yuedongsheng_cg{at}163.com cuixiaonan{at}tjmuch.com shilei{at}zjcc.org.cn
Dongsheng Yue
2Department of Lung Cancer, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Dongsheng Yue
  • For correspondence: yuedongsheng_cg{at}163.com cuixiaonan{at}tjmuch.com shilei{at}zjcc.org.cn
  • Article
  • Figures & Data
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Siegel RL,
    2. Kratzer TB,
    3. Giaquinto AN,
    4. Sung H,
    5. Jemal A.
    Cancer statistics, 2025. CA Cancer J Clin. 2025; 75: 10–45.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Zheng S,
    2. Liu J,
    3. Xie J,
    4. Zhang W,
    5. Bian K,
    6. Liang J, et al.
    Differentiating high-grade patterns and predominant subtypes for IASLC grading in invasive pulmonary adenocarcinoma using radiomics and clinical-semantic features. Cancer Imaging. 2025; 25: 42.
    OpenUrlPubMed
  3. 3.↵
    1. Wozniak AJ,
    2. Gadgeel SM.
    Adjuvant therapy for resected non-small cell lung cancer. Ther Adv Med Oncol. 2009; 1: 109–18.
    OpenUrlCrossRefPubMed
  4. 4.↵
    1. Felip E,
    2. Altorki N,
    3. Zhou C,
    4. Vallières E,
    5. Martínez-Martí A,
    6. Rittmeyer A, et al.
    Overall survival with adjuvant atezolizumab after chemotherapy in resected stage II–IIIA non-small-cell lung cancer (IMpower010): a randomised, multicentre, open-label, phase III trial. Ann Oncol. 2023; 34: 907–19.
    OpenUrlCrossRefPubMed
  5. 5.↵
    1. Yue D,
    2. Wang W,
    3. Liu H,
    4. Chen Q,
    5. Chen C,
    6. Zhang J, et al.
    LBA58 pathological response to neoadjuvant tislelizumab (TIS) plus platinum-doublet (PtDB) chemotherapy (CT) in resectable stage II–IIIA NSCLC patients (pts) in the phase III (Ph3) RATIONALE-315 trial. Ann Oncol. 2023; 34: S1299.
    OpenUrl
  6. 6.
    1. Forde PM,
    2. Spicer J,
    3. Lu S,
    4. Provencio M,
    5. Mitsudomi T,
    6. Awad MM, et al.
    Neoadjuvant nivolumab plus chemotherapy in resectable lung cancer. N Engl J Med. 2022; 386: 1973–85.
    OpenUrlCrossRefPubMed
  7. 7.↵
    1. Heymach JV,
    2. Harpole D,
    3. Mitsudomi T,
    4. Taube JM,
    5. Galffy G,
    6. Hochmair M, et al.
    Perioperative durvalumab for resectable non-small-cell lung cancer. N Engl J Med. 2023; 389: 1672–84.
    OpenUrlCrossRefPubMed
  8. 8.
    1. Wakelee H,
    2. Liberman M,
    3. Kato T,
    4. Tsuboi M,
    5. Lee S-H,
    6. Gao S, et al.
    Perioperative pembrolizumab for early-stage non-small-cell lung cancer. N Engl J Med. 2023; 389: 491–503.
    OpenUrlCrossRefPubMed
  9. 9.
    1. Lu S,
    2. Zhang W,
    3. Wu L,
    4. Wang W,
    5. Zhang P,
    6. Fang W, et al.
    Perioperative toripalimab plus chemotherapy for patients with resectable non-small cell lung cancer: the neotorch randomized clinical trial. JAMA. 2024; 331: 201–11.
    OpenUrlCrossRefPubMed
  10. 10.
    1. Cascone T,
    2. Awad M,
    3. Spicer J,
    4. He J,
    5. Lu S,
    6. Sepesi B, et al.
    LBA1 CheckMate 77T: phase III study comparing neoadjuvant nivolumab (NIVO) plus chemotherapy (chemo) vs neoadjuvant placebo plus chemo followed by surgery and adjuvant NIVO or placebo for previously untreated, resectable stage II–IIIb NSCLC. Ann Oncol. 2023; 34: S1295.
    OpenUrl
  11. 11.↵
    1. Forde P,
    2. Spicer J,
    3. Girard N,
    4. Provencio M,
    5. Lu S,
    6. Wang C, et al.
    84O Neoadjuvant nivolumab (N) + platinum-doublet chemotherapy (C) for resectable NSCLC: 3-y update from CheckMate 816. J Thorac Oncol. 2023; 18: S89–90.
    OpenUrl
  12. 12.↵
    1. Provencio M,
    2. Nadal E,
    3. Insa A,
    4. García-Campelo MR,
    5. Casal-Rubio J,
    6. Dómine M, et al.
    Neoadjuvant chemotherapy and nivolumab in resectable non-small-cell lung cancer (NADIM): an open-label, multicentre, single-arm, phase 2 trial. Lancet Oncol. 2020; 21: 1413–22.
    OpenUrlCrossRefPubMed
  13. 13.↵
    1. Zheng S,
    2. Cui X,
    3. Ye Z.
    Integrating artificial intelligence into radiological cancer imaging: from diagnosis and treatment response to prognosis. Cancer Biol Med. 2025; 22: 6–13.
    OpenUrlFREE Full Text
  14. 14.↵
    1. Yang M,
    2. Li X,
    3. Cai C,
    4. Liu C,
    5. Ma M,
    6. Qu W, et al.
    [18F]FDG PET-CT radiomics signature to predict pathological complete response to neoadjuvant chemoimmunotherapy in non-small cell lung cancer: a multicenter study. Eur Radiol. 2024; 34: 4352–63.
    OpenUrlPubMed
  15. 15.↵
    1. Yang N,
    2. Yue HL,
    3. Zhang BH,
    4. Chen J,
    5. Chu Q,
    6. Wang JX, et al.
    Predicting pathological response to neoadjuvant or conversion chemoimmunotherapy in stage IB-III non-small cell lung cancer patients using radiomic features. Thorac Cancer. 2023; 14: 2869–76.
    OpenUrlPubMed
  16. 16.↵
    1. Travis WD,
    2. Dacic S,
    3. Wistuba I,
    4. Sholl L,
    5. Adusumilli P,
    6. Bubendorf L, et al.
    IASLC multidisciplinary recommendations for pathologic assessment of lung cancer resection specimens after neoadjuvant therapy. J Thorac Oncol. 2020; 15: 709–40.
    OpenUrlPubMed
  17. 17.↵
    1. Yang C,
    2. Huang M,
    3. Li S,
    4. Chen J,
    5. Yang Y,
    6. Qin N, et al.
    Radiomics model of magnetic resonance imaging for predicting pathological grading and lymph node metastases of extrahepatic cholangiocarcinoma. Cancer Lett. 2020; 470: 1–7.
    OpenUrlPubMed
  18. 18.↵
    1. Lundberg SM,
    2. Lee S-I.
    A unified approach to interpreting model predictions. In: Proceedings of the 31st International Conference on Neural Information Processing Systems (NIPS’17). Red Hook, NY, USA: Curran Associates Inc.; 2017: 4768–77.
  19. 19.↵
    1. Plackett RL.
    Karl pearson and the chi-squared test. Int Stat Rev. 1983; 51: 59–72.
    OpenUrl
  20. 20.
    1. Kim TK.
    T test as a parametric statistic. Korean J Anesthesiol. 2015; 68: 540–6.
    OpenUrlCrossRefPubMed
  21. 21.↵
    1. Ostertagova E,
    2. Ostertag O,
    3. Kováč J.
    Methodology and application of the Kruskal–Wallis test. Appl Mech Mater. 2014; 611: 115–20.
    OpenUrl
  22. 22.↵
    1. DeLong ER,
    2. DeLong DM,
    3. Clarke-Pearson DL.
    Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988; 837–45.
  23. 23.↵
    1. Bao X,
    2. Peng Q,
    3. Bian D,
    4. Ni J,
    5. Zhou S,
    6. Zhang P, et al.
    Short-term intra-and peri-tumoral spatiotemporal CT radiomics for predicting major pathological response to neoadjuvant chemoimmunotherapy in non-small cell lung cancer. Eur Radiol. 2025; 35: 6052–64.
    OpenUrlPubMed
  24. 24.↵
    1. Ye G,
    2. Wu G,
    3. Qi Y,
    4. Li K,
    5. Wang M,
    6. Zhang C, et al.
    Non-invasive multimodal CT deep learning biomarker to predict pathological complete response of non-small cell lung cancer following neoadjuvant immunochemotherapy: a multicenter study. J Immunother Cancer. 2024; 12: e009348.
  25. 25.↵
    1. Eze C,
    2. Schmidt-Hegemann N-S,
    3. Sawicki LM,
    4. Kirchner J,
    5. Roengvoraphoj O,
    6. Käsmann L, et al.
    PET/CT imaging for evaluation of multimodal treatment efficacy and toxicity in advanced NSCLC—current state and future directions. Eur J Nucl Med Mol Imaging. 2021; 48: 3975–89.
    OpenUrlPubMed
  26. 26.↵
    1. Gao P,
    2. Xiao Q,
    3. Tan H,
    4. Song J,
    5. Fu Y,
    6. Xu J, et al.
    Interpretable multi-modal artificial intelligence model for predicting gastric cancer response to neoadjuvant chemotherapy. Cell Rep Med. 2024; 5: 101848.
  27. 27.↵
    1. Jiang C,
    2. Zhang X,
    3. Qu T,
    4. Yang X,
    5. Xiu Y,
    6. Yu X, et al.
    The prediction of pCR and chemosensitivity for breast cancer patients using DLG3, RADL and Pathomics signatures based on machine learning and deep learning. Transl Oncol. 2024; 46: 101985.
PreviousNext
Back to top

In this issue

Cancer Biology & Medicine: 23 (1)
Cancer Biology & Medicine
Vol. 23, Issue 1
15 Jan 2026
  • Table of Contents
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Cancer Biology & Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Temporal radiomics for non-invasive preoperative prediction of pathologic complete response to neoadjuvant chemoimmunotherapy in non-small cell lung cancer
(Your Name) has sent you a message from Cancer Biology & Medicine
(Your Name) thought you would like to see the Cancer Biology & Medicine web site.
Citation Tools
Temporal radiomics for non-invasive preoperative prediction of pathologic complete response to neoadjuvant chemoimmunotherapy in non-small cell lung cancer
Sunyi Zheng, Shuo Wang, Ziwei Feng, Jing Liang, Jiaxin Liu, Xiaomeng Yang, Zhanshuo Zhang, Yuechen Cui, Jiping Xie, Shuxuan Fan, Jing Wang, Guoqing Liao, Haiyu Zhou, Zhaoxiang Ye, Jianyu Xiao, Lei Shi, Xiaonan Cui, Dongsheng Yue
Cancer Biology & Medicine Jan 2026, 20250327; DOI: 10.20892/j.issn.2095-3941.2025.0327

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Temporal radiomics for non-invasive preoperative prediction of pathologic complete response to neoadjuvant chemoimmunotherapy in non-small cell lung cancer
Sunyi Zheng, Shuo Wang, Ziwei Feng, Jing Liang, Jiaxin Liu, Xiaomeng Yang, Zhanshuo Zhang, Yuechen Cui, Jiping Xie, Shuxuan Fan, Jing Wang, Guoqing Liao, Haiyu Zhou, Zhaoxiang Ye, Jianyu Xiao, Lei Shi, Xiaonan Cui, Dongsheng Yue
Cancer Biology & Medicine Jan 2026, 20250327; DOI: 10.20892/j.issn.2095-3941.2025.0327
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and methods
    • Results
    • Discussion
    • Conclusions
    • Supporting Information
    • Conflict of interest statement
    • Authors contributions
    • Data availability statement
    • Acknowledgements
    • References
  • Figures & Data
  • Info & Metrics
  • References
  • PDF

Related Articles

  • No related articles found.
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Psychological health mediates the association between diet and upper gastrointestinal cancer: a cross-sectional analysis from a large-scale population-based screening project
  • Exosomal EPHA2 transfers metastatic potential by stabilizing TGF-βRI and activating the TGF-β/SMAD3 signaling pathway in breast cancer
  • Single-cell and spatial transcriptome analyses reveal tumor immunometabolism in lymph node metastasis of lung cancer
Show more Original Article

Similar Articles

Keywords

  • Non-small cell lung cancer
  • radiomics
  • pathologic complete response
  • neoadjuvant therapy
  • computed tomography

Navigate

  • Home
  • Current Issue

More Information

  • About CBM
  • About CACA
  • About TMUCIH
  • Editorial Board
  • Subscription

For Authors

  • Instructions for authors
  • Journal Policies
  • Submit a Manuscript

Journal Services

  • Email Alerts
  • Facebook
  • RSS Feeds
  • Twitter

 

© 2026 Cancer Biology & Medicine

Powered by HighWire