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LetterLetter
Open Access

Impact of pre-neoadjuvant radioactive iodine seed marking on pathologic complete response and survival in early-stage breast cancer patients

Yihao Geng, Qi Zhang, Zhao Bi, Zhiqiang Shi, Qiuchen Zhao, Xiaowei Qi, Rongrong Zhao, Yongsheng Wang and Pengfei Qiu
Cancer Biology & Medicine December 2025, 20250578; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0578
Yihao Geng
1Breast Cancer Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China
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Qi Zhang
1Breast Cancer Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China
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Zhao Bi
1Breast Cancer Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China
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Zhiqiang Shi
1Breast Cancer Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China
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Qiuchen Zhao
2Cancer Research UK Cambridge Centre and Department of Oncology, University of Cambridge, Cambridge CB2 0XZ, UK
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Xiaowei Qi
3Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing 400038, China
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Rongrong Zhao
1Breast Cancer Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China
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  • ORCID record for Rongrong Zhao
  • For correspondence: zhaorongrong2002{at}126.com yswang{at}sdfmu.edu.cn qiu.pf{at}outlook.com
Yongsheng Wang
1Breast Cancer Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China
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  • ORCID record for Yongsheng Wang
  • For correspondence: zhaorongrong2002{at}126.com yswang{at}sdfmu.edu.cn qiu.pf{at}outlook.com
Pengfei Qiu
1Breast Cancer Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China
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  • For correspondence: zhaorongrong2002{at}126.com yswang{at}sdfmu.edu.cn qiu.pf{at}outlook.com
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Article Information

20250578
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2025.0578

Published By 
Cancer Biology & Medicine
History 
  • Received September 23, 2025
  • Accepted November 19, 2025
  • Published online December 26, 2025.

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  • You are currently viewing a previous version of this article (December 26, 2025 - 06:10).
  • View the most recent version of this article
Copyright & Usage 
Copyright: © 2025, The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Author Information

Funding

  • National Natural Science Foundation of China

    82573747
  • National Natural Science Foundation of China

    82172873
  • National Natural Science Foundation of China

    W2421095
  • National Natural Science Foundation of China

    82503888
  • National Science and Technology Major Project

    2025ZD0543900
  • Natural Science Foundation of Shandong Province

    ZR2024LMB011
  • Natural Science Foundation of Shandong Province

    ZR2024QH058
  • Taishan Scholars Program of Shandong Province

    tsqn202211337
  • Collaborative Academic Innovation Project of Shandong Cancer Hospital

    GF003

This work was supported by grants from the National Natural Science Foundation of China (Grant Nos. 82573747, 82172873, W2421095, and 82503888), National Science and Technology Major Project (Grant No. 2025ZD0543900), Natural Science Foundation of Shandong Province (Grant Nos. ZR2024LMB011 and ZR2024QH058), Taishan Scholars Program of Shandong Province (Grant No. tsqn202211337), and Collaborative Academic Innovation Project of Shandong Cancer Hospital (Grant No. GF003).

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Cancer Biology & Medicine: 23 (2)
Cancer Biology & Medicine
Vol. 23, Issue 2
15 Feb 2026
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Impact of pre-neoadjuvant radioactive iodine seed marking on pathologic complete response and survival in early-stage breast cancer patients
Yihao Geng, Qi Zhang, Zhao Bi, Zhiqiang Shi, Qiuchen Zhao, Xiaowei Qi, Rongrong Zhao, Yongsheng Wang, Pengfei Qiu
Cancer Biology & Medicine Dec 2025, 20250578; DOI: 10.20892/j.issn.2095-3941.2025.0578

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Impact of pre-neoadjuvant radioactive iodine seed marking on pathologic complete response and survival in early-stage breast cancer patients
Yihao Geng, Qi Zhang, Zhao Bi, Zhiqiang Shi, Qiuchen Zhao, Xiaowei Qi, Rongrong Zhao, Yongsheng Wang, Pengfei Qiu
Cancer Biology & Medicine Dec 2025, 20250578; DOI: 10.20892/j.issn.2095-3941.2025.0578
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  • Article
    • Clinicopathologic characteristics
    • 125I seed marking protocol
    • Logistic regression analyses of pCR and cohort construction via PSM
    • pCR outcomes with 125I seed marking in the matched cohort
    • Correlation between 125I seed marking and long-term prognosis
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