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LetterLetter
Open Access

COX-2 inhibition synergizes with radioimmunotherapy by promoting TCF1+CD8+ T cell infiltration in NSCLC

Lin Ma, Menglin Bai, Yao Wang, Xueying Zhai, Jinming Yu and Xiangjiao Meng
Cancer Biology & Medicine October 2025, 20250205; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0205
Lin Ma
1Department of Radiation Oncology, Shandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China
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Menglin Bai
2Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan 250012, China
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Yao Wang
3Department of Radiation Oncology, Fujian Medical University, Fuzhou 350001, China
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Xueying Zhai
1Department of Radiation Oncology, Shandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China
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Jinming Yu
1Department of Radiation Oncology, Shandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China
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  • ORCID record for Jinming Yu
  • For correspondence: sdyujinming{at}163.com mengxiangjiao{at}sina.com
Xiangjiao Meng
1Department of Radiation Oncology, Shandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China
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  • For correspondence: sdyujinming{at}163.com mengxiangjiao{at}sina.com
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Article Information

20250205
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2025.0205

Published By 
Cancer Biology & Medicine
History 
  • Received May 26, 2025
  • Accepted September 9, 2025
  • Published online October 22, 2025.

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  • You are currently viewing a previous version of this article (October 22, 2025 - 00:09).
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Copyright & Usage 
Copyright: © 2025, The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Author Information

Funding

  • National Natural Science Foundation of China

    82030082
  • National Natural Science Foundation of China

    82272845
  • Natural Science Foundation of Shandong Province

    ZR2023LZL001

This work was funded by the National Natural Science Foundation of China (Grant Nos. 82030082 and 82272845) and the Natural Science Foundation of Shandong Province (Grant No. ZR2023LZL001).

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Cancer Biology & Medicine: 22 (12)
Cancer Biology & Medicine
Vol. 22, Issue 12
15 Dec 2025
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COX-2 inhibition synergizes with radioimmunotherapy by promoting TCF1+CD8+ T cell infiltration in NSCLC
Lin Ma, Menglin Bai, Yao Wang, Xueying Zhai, Jinming Yu, Xiangjiao Meng
Cancer Biology & Medicine Oct 2025, 20250205; DOI: 10.20892/j.issn.2095-3941.2025.0205

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COX-2 inhibition synergizes with radioimmunotherapy by promoting TCF1+CD8+ T cell infiltration in NSCLC
Lin Ma, Menglin Bai, Yao Wang, Xueying Zhai, Jinming Yu, Xiangjiao Meng
Cancer Biology & Medicine Oct 2025, 20250205; DOI: 10.20892/j.issn.2095-3941.2025.0205
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    • Upregulation of the COX-2/PGE2 axis impairs radioimmunotherapy efficacy
    • COX-2 inhibition with celecoxib enhances radioimmunotherapy efficacy
    • COX-2 expression and TCF1+CD8+ T cell infiltration as prognostic markers in radioimmunotherapy-naïve NSCLC
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