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LetterLetter
Open Access

Phase I clinical study of humanized BCMA-single-domain antibodies targeting CAR-T in patients with relapsed or refractory multiple myeloma

Gaofeng Zheng, Ruyi Xu, Heng Mei, Xiaoyan Han, Donghua He, Yanling Weng, Cheng Wen, Zhuoxiao Cao and Zhen Cai
Cancer Biology & Medicine October 2025, 20240581; DOI: https://doi.org/10.20892/j.issn.2095-3941.2024.0581
Gaofeng Zheng
1Multiple Myeloma Treatment Center and Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
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Ruyi Xu
1Multiple Myeloma Treatment Center and Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
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Heng Mei
2Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
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Xiaoyan Han
1Multiple Myeloma Treatment Center and Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
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Donghua He
1Multiple Myeloma Treatment Center and Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
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Yanling Weng
1Multiple Myeloma Treatment Center and Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
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Cheng Wen
3Shanghai Simnova Biotechnology Co., Ltd, Shanghai 200120, China
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Zhuoxiao Cao
3Shanghai Simnova Biotechnology Co., Ltd, Shanghai 200120, China
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Zhen Cai
1Multiple Myeloma Treatment Center and Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
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  • ORCID record for Zhen Cai
  • For correspondence: caiz{at}zju.edu.cn
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References

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Cancer Biology & Medicine: 22 (12)
Cancer Biology & Medicine
Vol. 22, Issue 12
15 Dec 2025
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Phase I clinical study of humanized BCMA-single-domain antibodies targeting CAR-T in patients with relapsed or refractory multiple myeloma
Gaofeng Zheng, Ruyi Xu, Heng Mei, Xiaoyan Han, Donghua He, Yanling Weng, Cheng Wen, Zhuoxiao Cao, Zhen Cai
Cancer Biology & Medicine Oct 2025, 20240581; DOI: 10.20892/j.issn.2095-3941.2024.0581

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Phase I clinical study of humanized BCMA-single-domain antibodies targeting CAR-T in patients with relapsed or refractory multiple myeloma
Gaofeng Zheng, Ruyi Xu, Heng Mei, Xiaoyan Han, Donghua He, Yanling Weng, Cheng Wen, Zhuoxiao Cao, Zhen Cai
Cancer Biology & Medicine Oct 2025, 20240581; DOI: 10.20892/j.issn.2095-3941.2024.0581
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  • Article
    • Clinical characteristics and disposition
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