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Open Access

Immunological and metabolic optimization of tumor neoantigen vaccines

Xiafeng Wang, Zhangping Huang, Lin Peng, Shuoxi Xu, Jianfeng Huang and Ji Wang
Cancer Biology & Medicine September 2025, 20250445; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0445
Xiafeng Wang
Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 440100, China
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  • ORCID record for Xiafeng Wang
  • For correspondence: wangxf58{at}mail.sysu.edu.cn huangjf85{at}mail.sysu.edu.cn wangj683{at}mail.sysu.edu.cn
Zhangping Huang
Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 440100, China
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Lin Peng
Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 440100, China
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Shuoxi Xu
Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 440100, China
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Jianfeng Huang
Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 440100, China
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  • For correspondence: wangxf58{at}mail.sysu.edu.cn huangjf85{at}mail.sysu.edu.cn wangj683{at}mail.sysu.edu.cn
Ji Wang
Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 440100, China
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  • For correspondence: wangxf58{at}mail.sysu.edu.cn huangjf85{at}mail.sysu.edu.cn wangj683{at}mail.sysu.edu.cn
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Cancer Biology & Medicine: 23 (4)
Cancer Biology & Medicine
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15 Apr 2026
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Immunological and metabolic optimization of tumor neoantigen vaccines
Xiafeng Wang, Zhangping Huang, Lin Peng, Shuoxi Xu, Jianfeng Huang, Ji Wang
Cancer Biology & Medicine Sep 2025, 20250445; DOI: 10.20892/j.issn.2095-3941.2025.0445

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Immunological and metabolic optimization of tumor neoantigen vaccines
Xiafeng Wang, Zhangping Huang, Lin Peng, Shuoxi Xu, Jianfeng Huang, Ji Wang
Cancer Biology & Medicine Sep 2025, 20250445; DOI: 10.20892/j.issn.2095-3941.2025.0445
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  • Article
    • Sources of neoantigens
    • Neoantigen identification and design
    • Adjuvants for tumor neoantigen vaccines
    • Delivery system for tumor neoantigen vaccines
    • Metabolic effects on tumor neoantigen vaccines
    • Conclusion and future prospects
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