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Open Access

Immunological and metabolic optimization of tumor neoantigen vaccines

Xiafeng Wang, Zhangping Huang, Lin Peng, Shuoxi Xu, Jianfeng Huang and Ji Wang
Cancer Biology & Medicine September 2025, 20250445; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0445
Xiafeng Wang
Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 440100, China
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  • For correspondence: wangxf58{at}mail.sysu.edu.cn huangjf85{at}mail.sysu.edu.cn wangj683{at}mail.sysu.edu.cn
Zhangping Huang
Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 440100, China
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Lin Peng
Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 440100, China
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Shuoxi Xu
Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 440100, China
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Jianfeng Huang
Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 440100, China
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  • For correspondence: wangxf58{at}mail.sysu.edu.cn huangjf85{at}mail.sysu.edu.cn wangj683{at}mail.sysu.edu.cn
Ji Wang
Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 440100, China
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  • For correspondence: wangxf58{at}mail.sysu.edu.cn huangjf85{at}mail.sysu.edu.cn wangj683{at}mail.sysu.edu.cn
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Article Information

20250445
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2025.0445

Published By 
Cancer Biology & Medicine
History 
  • Received August 2, 2025
  • Accepted September 8, 2025
  • Published online September 30, 2025.

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  • You are currently viewing a previous version of this article (September 30, 2025 - 09:45).
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Copyright: © 2025, The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

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Funding

  • National Natural Science Foundation of China

    82341042
  • National Natural Science Foundation of China

    32270993

The work was supported by the National Natural Science Foundation of China (82341042 and 32270993) and the PhD program of the Interdisciplinary Research Center, Sun Yat-sen University.

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Cancer Biology & Medicine: 23 (4)
Cancer Biology & Medicine
Vol. 23, Issue 4
15 Apr 2026
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Immunological and metabolic optimization of tumor neoantigen vaccines
Xiafeng Wang, Zhangping Huang, Lin Peng, Shuoxi Xu, Jianfeng Huang, Ji Wang
Cancer Biology & Medicine Sep 2025, 20250445; DOI: 10.20892/j.issn.2095-3941.2025.0445

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Immunological and metabolic optimization of tumor neoantigen vaccines
Xiafeng Wang, Zhangping Huang, Lin Peng, Shuoxi Xu, Jianfeng Huang, Ji Wang
Cancer Biology & Medicine Sep 2025, 20250445; DOI: 10.20892/j.issn.2095-3941.2025.0445
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  • Article
    • Sources of neoantigens
    • Neoantigen identification and design
    • Adjuvants for tumor neoantigen vaccines
    • Delivery system for tumor neoantigen vaccines
    • Metabolic effects on tumor neoantigen vaccines
    • Conclusion and future prospects
    • Conflict of interest statement
    • Author contributions
    • References
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