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Review ArticleReview
Open Access

Mechanisms underlying prostate cancer sensitivity to reactive oxygen species: overcoming radiotherapy resistance and recent clinical advances

Meidan Wang, Rui Xing, Liqun Wang, Mingyue Pan, Ruoyun Zhang, Ting Li, Weiqiang Sun and Jing Zhou
Cancer Biology & Medicine July 2025, 20240584; DOI: https://doi.org/10.20892/j.issn.2095-3941.2024.0584
Meidan Wang
1Department of Radiation Oncology, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany
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Rui Xing
2Department of Hematology, Dongyang Hospital Affiliated to Wenzhou Medical University, Dongyang People’s Hospital, Dongyang 322100, China
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Liqun Wang
1Department of Radiation Oncology, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany
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Mingyue Pan
3Faculty of Law, University of Freiburg, Freiburg 79085, Germany
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Ruoyun Zhang
4School of Chinese Language and Literature, Tangshan Normal University, Tangshan 063000, China
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Ting Li
5Department of Oncology, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
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Weiqiang Sun
6Department of Hepatobiliary Surgery, General Surgery, Jinan Third People’s Hospital, Jinan 250031, China
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Jing Zhou
7Department of Chemoradiotherapy, Ningbo NO. 2 Hospital, Ningbo 315010, China
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  • ORCID record for Jing Zhou
  • For correspondence: zhoujing0077{at}outlook.com
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Cancer Biology & Medicine: 23 (7)
Cancer Biology & Medicine
Vol. 23, Issue 7
15 Jul 2026
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Mechanisms underlying prostate cancer sensitivity to reactive oxygen species: overcoming radiotherapy resistance and recent clinical advances
Meidan Wang, Rui Xing, Liqun Wang, Mingyue Pan, Ruoyun Zhang, Ting Li, Weiqiang Sun, Jing Zhou
Cancer Biology & Medicine Jul 2025, 20240584; DOI: 10.20892/j.issn.2095-3941.2024.0584

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Mechanisms underlying prostate cancer sensitivity to reactive oxygen species: overcoming radiotherapy resistance and recent clinical advances
Meidan Wang, Rui Xing, Liqun Wang, Mingyue Pan, Ruoyun Zhang, Ting Li, Weiqiang Sun, Jing Zhou
Cancer Biology & Medicine Jul 2025, 20240584; DOI: 10.20892/j.issn.2095-3941.2024.0584
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  • Article
    • Abstract
    • Introduction
    • Dual role of ROS in tumor biology and mechanisms underlying tumor resistance to oxidative stress
    • Role of ROS and ROS involvement during radiotherapy in PCa patients
    • ROS removal-associated radiotherapy resistance in PCa
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Keywords

  • Prostate cancer (PCa)
  • radiation therapy (RT)
  • reactive oxygen species (ROS)
  • radiotherapy resistance
  • antioxidants

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