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Research ArticleOriginal Article

Global, regional, and national burden of early-onset gastric cancer

Nuopei Tan, Hongliang Wu, Maomao Cao, Fan Yang, Xinxin Yan, Siyi He, Mengdi Cao, Shaoli Zhang, Yi Teng, Qianru Li, Jiachen Wang, Changfa Xia and Wanqing Chen
Cancer Biology & Medicine August 2024, 20240159; DOI: https://doi.org/10.20892/j.issn.2095-3941.2024.0159
Nuopei Tan
1Department of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Hongliang Wu
2Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Maomao Cao
1Department of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Fan Yang
1Department of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Xinxin Yan
1Department of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Siyi He
1Department of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Mengdi Cao
1Department of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Shaoli Zhang
1Department of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Yi Teng
1Department of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Qianru Li
1Department of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Jiachen Wang
1Department of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Changfa Xia
1Department of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Wanqing Chen
1Department of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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  • ORCID record for Wanqing Chen
  • For correspondence: chenwq{at}cicams.ac.cn
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    Figure 1

    Age-standardised incidence (A) and mortality (B) rates per 100,000 people of GC by gender, world region in 2022. M/F, male:female age-standardised rate ratio. UN, United Nations. Data are from the GLOBOCAN database, collated by the International Agency for Research on Cancer and hosted by the Global Cancer Observatory1.

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    Table 1

    New cases and deaths, age-standardised incidence and mortality rates per 100,000 persons with GC by age group and world region in 2022

    PopulationIncidenceMortality
    < 50 years≥ 50 years< 50 years≥ 50 years
    Number of cases% of all casesASRNumber of cases% of all casesASRNumber of cases% of all casesASRNumber of cases% of all casesASR
    Regions
     Africa
      East Africa2,30722.500.777,94677.5018.661,81220.140.607,18479.8616.90
      West Africa1,89124.390.735,86175.6115.461,61023.220.625,32376.7814.19
      Mid-Africa85224.550.782,61875.4515.9871023.230.652,34676.7714.40
      South Africa35117.380.581,66982.6214.7125414.850.431,45685.1513.09
      North Africa2,19022.221.087,66777.7817.261,68120.920.836,35479.0814.28
     America
      Caribbean46011.001.283,72089.0026.873169.870.872,88790.1320.52
      Central America2,06313.861.3212,82386.1431.41,65614.201.0610,00685.8024.29
      South America5,3619.691.3849,95290.3140.004,1619.671.0538,86990.3330.75
      North America2,9469.930.9626,72990.0716.831,1148.330.3612,25391.677.05
     Asia
      East Asia27,4435.271.84493,53294.7372.9112,7974.030.85305,12295.9742.66
      West Asia3,21214.451.2519,01285.5536.442,16111.980.8515,87388.0230.17
      Southeast Asia5,52614.240.9133,27285.7621.533,63511.460.6028,07788.5418.13
      South Central Asia19,39517.661.1090,39982.3423.3215,35216.170.8979,58983.8320.50
     Europe
      East Europe4,3686.581.5762,03293.4249.412,7445.650.9745,80494.3535.19
      West Europe1,5665.730.9825,77394.2723.977514.410.4616,29195.5913.64
      South Europe1,3074.240.9229,54095.7632.457583.410.5221,46696.5921.59
      North Europe6115.540.6810,41394.4618.973284.310.367,28995.6912.31
     Oceania
      Australia-New Zealand2296.870.873,10593.1322.71935.670.351,54694.3310.37
      Melanesia6411.850.7047688.1533.03276.310.3140193.6927.59
      Micronesia00.000.0040100.0032.3300.000.0028100.0023.01
      Polynesia46.350.755993.6537.1135.880.564894.1230.04
     HDI
      Low HDI country6,60925.700.8519,10874.3015.935,33023.450.7017,39876.5514.53
      Medium HDI country20,78618.451.1091,87281.5522.1315,89216.100.8582,82983.9019.94
      High HDI country36,6597.651.46442,68592.3551.0521,9776.180.87333,38493.8237.12
      Very HDI country18,0675.151.25332,70294.8543.258,7484.780.60174,37895.2221.01
    World82,1468.481.24886,63891.5240.9251,9637.870.79608,21292.1327.28

    ASR, age-standardised rate per 100,000 people; HDI, human development index.

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      Table 2

      Age-standardised incidence rates (ASIR) per 100,000 persons with GC by gender and years

      CountryMaleFemale
      2003–20072008–20122013–20172003–20072008–20122013–2017
      Austria11.7510.119.196.234.984.80
      Australia6.447.476.403.533.023.01
      Canada7.917.236.313.793.242.92
      China42.6642.5934.3220.2218.5615.53
      Colombia25.0120.1521.2712.0410.1310.38
      Denmark7.466.957.073.453.023.31
      France9.017.957.553.413.523.24
      Germany12.7210.6410.026.675.645.15
      India9.868.957.964.814.254.08
      Iceland9.185.905.095.014.293.38
      Ireland10.239.628.794.884.554.22
      Italy13.9112.2010.036.936.185.55
      Japan58.6756.5254.8321.3420.3220.02
      Korea, Republic of63.2661.7950.0625.5324.7321.23
      The Netherlands9.318.246.554.134.023.39
      New Zealand14.5815.2311.379.248.617.75
      Norway7.746.576.094.183.403.04
      Spain11.9111.259.675.115.074.88
      Switzerland8.337.797.724.304.013.74
      South Africa0.911.290.580.480.730.79
      Türkey14.5116.3714.047.117.426.01
      Uganda7.155.735.005.422.853.93
      United Kingdom9.968.437.284.363.733.25
      United States of America7.296.606.283.573.423.32
      • View popup
      Table 3

      Age-standardised incidence rates per 100,000 (< 50 and ≥ 50 years of age) persons with GC by gender and years

      Country< 50 years≥ 50 years
      MaleFemaleMaleFemale
      2003–20072008–20122013–20172003–20072008–20122013–20172003–20072008–20122013–20172003–20072008–20122013–2017
      Austria1.020.920.900.770.770.8510.739.208.285.474.213.95
      Australia0.510.830.740.440.520.505.946.645.663.092.502.51
      Canada0.630.890.620.790.780.397.286.345.693.012.462.52
      China4.033.463.122.752.832.3738.6339.1331.2017.4715.7313.16
      Colombia2.882.732.921.722.292.3022.1317.4218.3510.327.858.08
      Denmark0.850.650.710.560.490.586.606.306.372.892.532.73
      France0.930.860.900.550.500.618.087.096.662.853.032.63
      Germany1.331.101.131.010.820.9111.399.538.895.664.814.24
      India1.621.411.140.910.860.838.247.546.823.903.393.25
      Iceland0.660.530.550.730.450.348.525.374.554.273.833.04
      Ireland0.810.750.890.560.670.599.428.877.904.323.883.63
      Italy1.201.170.931.030.890.8112.7011.049.095.905.304.74
      Japan5.233.643.153.472.812.6853.4452.8951.6817.8717.5117.34
      Korea, Republic of8.377.876.366.236.095.4654.8953.9343.7019.3118.6415.77
      The Netherlands0.840.770.680.590.690.578.467.475.873.543.322.82
      New Zealand2.022.371.772.171.941.4512.5612.859.607.076.676.31
      Norway0.550.670.510.580.390.527.195.895.583.613.012.52
      Spain1.241.150.860.930.770.8110.6610.108.814.184.294.08
      Switzerland0.911.020.860.890.750.827.426.766.863.413.262.92
      South Africa0.080.480.000.050.230.070.830.800.580.430.500.71
      Türkey2.321.952.071.861.451.3912.2014.4111.965.255.984.62
      Uganda0.850.870.721.130.340.496.304.864.284.292.513.44
      United Kingdom0.700.650.650.490.540.439.267.796.623.873.192.81
      United States of America0.840.800.810.610.610.676.455.805.472.962.802.64

    Supplementary Materials

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    Global, regional, and national burden of early-onset gastric cancer
    Nuopei Tan, Hongliang Wu, Maomao Cao, Fan Yang, Xinxin Yan, Siyi He, Mengdi Cao, Shaoli Zhang, Yi Teng, Qianru Li, Jiachen Wang, Changfa Xia, Wanqing Chen
    Cancer Biology & Medicine Aug 2024, 20240159; DOI: 10.20892/j.issn.2095-3941.2024.0159

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    Global, regional, and national burden of early-onset gastric cancer
    Nuopei Tan, Hongliang Wu, Maomao Cao, Fan Yang, Xinxin Yan, Siyi He, Mengdi Cao, Shaoli Zhang, Yi Teng, Qianru Li, Jiachen Wang, Changfa Xia, Wanqing Chen
    Cancer Biology & Medicine Aug 2024, 20240159; DOI: 10.20892/j.issn.2095-3941.2024.0159
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