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Original ArticleOriginal Article

Attributable liver cancer deaths and disability-adjusted life years in China and worldwide: profiles and changing trends

Mengdi Cao, Changfa Xia, Maomao Cao, Fan Yang, Xinxin Yan, Siyi He, Shaoli Zhang, Yi Teng, Qianru Li, Nuopei Tan, Jiachen Wang and Wanqing Chen
Cancer Biology & Medicine July 2024, 20240149; DOI: https://doi.org/10.20892/j.issn.2095-3941.2024.0149
Mengdi Cao
Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Changfa Xia
Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Maomao Cao
Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Fan Yang
Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Xinxin Yan
Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Siyi He
Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Shaoli Zhang
Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Yi Teng
Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Qianru Li
Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Nuopei Tan
Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Jiachen Wang
Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Wanqing Chen
Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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  • ORCID record for Wanqing Chen
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  • Figure 1
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    Figure 1

    Age-specific deaths and DALYs numbers and rates of liver cancer worldwide and in China in 2019. (A) Global deaths. (B) Global DALYs. (C) China deaths. (D) China DALYs. DALYs, disability-adjusted life years.

  • Figure 2
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    Figure 2

    Proportional deaths burden of liver cancer etiologies by age groups worldwide and in China in 2019. (A) Global both genders. (B) Global males. (C) Global females. (D) China both genders. (E) China males. (F) China females.

  • Figure 3
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    Figure 3

    Proportion of deaths attributable to etiologies and risk factors of liver cancer by SDI and GBD regions in 2019. (A) Attributable to different etiologies for both genders. (B) Attributable to different risk factors for both genders. (C) Attributable to different etiologies for males. (D) Attributable to different risk factors for males. (E) Attributable to different etiologies for females. (F) Attributable to different risk factors for females. SDI, sociodemographic index; GBD, Global Burden of Diseases.

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    Figure 4

    Trends in attributable age-standardized deaths and DALYs rates (per 100,000 population) for liver cancer by SDI and GBD regions, 1990–2019. (A) Trends in age-standardized death rates for males. (B) Trends in age-standardized death rates for females. (C) Trends in age-standardized DALY rates for males. (D) Trends in age-standardized DALY rates for females. DALYs, disability-adjusted life years; SDI, sociodemographic index; GBD, Global Burden of Diseases; AAPC, average annual percent change.

Tables

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    Table 1

    Deaths and DALYs of liver cancer worldwide, by SDI and GBD regions in 2019

    RegionsDeathsDALYs
    BothMaleFemaleBothMaleFemale
    NumberASRNumberASRNumberASRNumberASRNumberASRNumberASR
    World484,576.65.9333,672.68.7150,904.13.512,528,421.5151.19,048,722.6225.33,479,698.981.3
    China187,699.69.4139,025.614.648,674.04.85,325,460.7264.34,145,795.1414.91,179,665.6115.9
    SDI
     Low SDI country20,756.03.913,029.55.17,726.52.8663,783.6101.2406,359.2128.9257,424.474.2
     Low-middle SDI country572,40.74.236,287.45.520,953.33.01,616,487.8109.01,049,300.3144.6567,187.575.2
     Middle SDI country196,958.97.9141,249.611.755,709.34.45,463,765.1206.94,102,975.5315.51,360,789.7103.0
     High-middle SDI country97,189.34.867,566.57.429,622.82.62,502,034.3127.31,850,349.5197.9651,684.862.1
     High SDI country112,239.95.975,412.08.936,827.93.32,277,515.6133.11,636,422.5203.0641,093.168.1
    Region
     Central Europe7,201.63.44,555.85.02,645.82.1156,613.979.1104,221.1116.452,392.847.8
     Eastern Europe9,675.82.95,635.94.44,039.91.9234,700.674.9148,008.2114.086,692.446.7
     Western Europe40,296.14.426,576.56.613,719.62.5787,716.698.5552,244.9147.9235,471.653.5
     Central Asia6,191.38.73,648.211.82,543.06.5172,829.7213.5106,480.2289.266,349.4152.6
     East Asia193,863.99.4143,103.314.450,760.74.85,491,479.5263.44,264,611.4412.71,226,868.1116.2
     South Asia38,650.32.824,175.43.614,474.92.11,085,515.471.3680,958.590.0404,556.952.9
     Southeast Asia42,862.17.329,273.310.813,588.84.41,149,098.1177.5821,270.6265.0327,827.599.3
     High-income Asia Pacific49,684.610.833,264.716.916,419.95.5920,379.3238.6673,678.6380.9246,700.7105.6
     Oceania232.83.5164.54.868.32.17,093.485.44,966.5117.02,126.951.9
     Australasia2,006.04.11,336.15.9669.92.543,655.098.130,413.4142.913,241.656.3
     High-income North America26,479.44.318,143.16.48,336.32.4608,194.5105.5435,713.6158.9172,480.956.6
     Caribbean1,694.93.31,065.74.4629.22.341,275.680.726,381.3108.014,894.355.9
     Andean Latin America1,840.03.3918.53.5921.63.244,339.677.323,035.982.521,303.772.2
     Central Latin America8,415.93.64,606.34.43,809.73.0197,475.182.8109,858.299.087,616.968.7
     Tropical Latin America5,939.52.53,776.33.62,163.21.6142,718.958.692,266.082.450,452.938.6
     Southern Latin America2,027.22.41,256.03.5771.31.643,534.453.627,961.575.915,572.935.0
     North Africa and Middle East26,432.46.218,866.78.67,565.73.7731,622.2153.3525,982.1214.7205,640.188.9
     Central Sub-Saharan Africa1,394.52.5758.43.2636.02.051,448.465.327,386.378.224,062.155.7
     Eastern Sub-Saharan Africa5,676.53.43,275.14.22,401.42.7187,943.585.5105,595.1103.482,348.469.0
     Southern Sub-Saharan Africa4,039.97.12,571.010.51,468.94.6122,194.8188.882,434.3281.339,760.5114.2
     Western Sub-Saharan Africa9,971.95.36,701.67.53,270.33.3308,593.0130.8205,254.7184.2103,338.381.9

    DALYs, disability-adjusted life years; SDI, sociodemographic index; GBD, Global Burden of Diseases; ASR, age-standardized rates.

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    Cancer Biology & Medicine: 22 (11)
    Cancer Biology & Medicine
    Vol. 22, Issue 11
    15 Nov 2025
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    Attributable liver cancer deaths and disability-adjusted life years in China and worldwide: profiles and changing trends
    Mengdi Cao, Changfa Xia, Maomao Cao, Fan Yang, Xinxin Yan, Siyi He, Shaoli Zhang, Yi Teng, Qianru Li, Nuopei Tan, Jiachen Wang, Wanqing Chen
    Cancer Biology & Medicine Jul 2024, 20240149; DOI: 10.20892/j.issn.2095-3941.2024.0149

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    Attributable liver cancer deaths and disability-adjusted life years in China and worldwide: profiles and changing trends
    Mengdi Cao, Changfa Xia, Maomao Cao, Fan Yang, Xinxin Yan, Siyi He, Shaoli Zhang, Yi Teng, Qianru Li, Nuopei Tan, Jiachen Wang, Wanqing Chen
    Cancer Biology & Medicine Jul 2024, 20240149; DOI: 10.20892/j.issn.2095-3941.2024.0149
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    Keywords

    • Liver cancer
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    • global
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