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Research ArticleOriginal Article

Enhancement of anti-PD-L1 antibody plus anlotinib efficacy due to downregulation of PD-L1 in the micro-conduit endothelium within the tumor: a randomized double-blind trial

Cuicui Zhang, Tianqing Chu, Qiming Wang, Ying Cheng, Yongxiang Zhang, Ruili Wang, Leilei Ma, Chaonan Qian, Baohui Han and Kai Li
Cancer Biology & Medicine May 2024, 20230423; DOI: https://doi.org/10.20892/j.issn.2095-3941.2023.0423
Cuicui Zhang
1Department of Thoracic Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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Tianqing Chu
2Department of Respiratory Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China
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Qiming Wang
3Department of Internal Medicine, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450003, China
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Ying Cheng
4Department of Thoracic Medical Oncology, Jilin Cancer Hospital, Changchun 130012, China
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Yongxiang Zhang
5Department of Respiratory & Critical Care Medicine, Tianjin Chest Hospital, Tianjin 300222, China
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Ruili Wang
6Panovue Biotechnology (Beijing) Co., Ltd, Beijing 100096, China
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Leilei Ma
7Medical Affairs Department, Chia-Tai Tian Qing Pharmaceutical Co., Ltd., Nanjing 210046, China
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Chaonan Qian
8Department of Radiation Oncology, Guangzhou Concord Cancer Center, Guangzhou 510555, China
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  • For correspondence: chaonan.qian{at}ccm.cn 18930858216{at}163.com likai_fnk{at}163.com
Baohui Han
2Department of Respiratory Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China
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  • For correspondence: chaonan.qian{at}ccm.cn 18930858216{at}163.com likai_fnk{at}163.com
Kai Li
1Department of Thoracic Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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  • For correspondence: chaonan.qian{at}ccm.cn 18930858216{at}163.com likai_fnk{at}163.com
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Cancer Biology & Medicine: 23 (7)
Cancer Biology & Medicine
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15 Jul 2026
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Enhancement of anti-PD-L1 antibody plus anlotinib efficacy due to downregulation of PD-L1 in the micro-conduit endothelium within the tumor: a randomized double-blind trial
Cuicui Zhang, Tianqing Chu, Qiming Wang, Ying Cheng, Yongxiang Zhang, Ruili Wang, Leilei Ma, Chaonan Qian, Baohui Han, Kai Li
Cancer Biology & Medicine May 2024, 20230423; DOI: 10.20892/j.issn.2095-3941.2023.0423

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Enhancement of anti-PD-L1 antibody plus anlotinib efficacy due to downregulation of PD-L1 in the micro-conduit endothelium within the tumor: a randomized double-blind trial
Cuicui Zhang, Tianqing Chu, Qiming Wang, Ying Cheng, Yongxiang Zhang, Ruili Wang, Leilei Ma, Chaonan Qian, Baohui Han, Kai Li
Cancer Biology & Medicine May 2024, 20230423; DOI: 10.20892/j.issn.2095-3941.2023.0423
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Keywords

  • PD-L1
  • lymphatic endothelial cell
  • blood endothelial cell
  • anlotinib
  • progression-free survival

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