Skip to main content

Main menu

  • Home
  • About
    • About CBM
    • Editorial Board
    • Announcement
  • Articles
    • Ahead of print
    • Current Issue
    • Archive
    • Collections
    • Cover Story
  • For Authors
    • Instructions for Authors
    • Resources
    • Submit a Manuscript
  • For Reviewers
    • Become a Reviewer
    • Instructions for Reviewers
    • Resources
    • Outstanding Reviewer
  • Subscription
  • Alerts
    • Email Alerts
    • RSS Feeds
    • Table of Contents
  • Contact us
  • Other Publications
    • cbm

User menu

  • My alerts

Search

  • Advanced search
Cancer Biology & Medicine
  • Other Publications
    • cbm
  • My alerts
Cancer Biology & Medicine

Advanced Search

 

  • Home
  • About
    • About CBM
    • Editorial Board
    • Announcement
  • Articles
    • Ahead of print
    • Current Issue
    • Archive
    • Collections
    • Cover Story
  • For Authors
    • Instructions for Authors
    • Resources
    • Submit a Manuscript
  • For Reviewers
    • Become a Reviewer
    • Instructions for Reviewers
    • Resources
    • Outstanding Reviewer
  • Subscription
  • Alerts
    • Email Alerts
    • RSS Feeds
    • Table of Contents
  • Contact us
  • Follow cbm on Twitter
  • Visit cbm on Facebook
EditorialEditorial

DNA methylation profiles in cancer: functions, therapy, and beyond

Jinrong Zhu, Yongjie Yang, Li Li, Jiuren Tang and Rongxin Zhang
Cancer Biology & Medicine December 2023, 20230403; DOI: https://doi.org/10.20892/j.issn.2095-3941.2023.0403
Jinrong Zhu
Laboratory of Immunology and Inflammation, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yongjie Yang
Laboratory of Immunology and Inflammation, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Li Li
Laboratory of Immunology and Inflammation, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jiuren Tang
Laboratory of Immunology and Inflammation, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rongxin Zhang
Laboratory of Immunology and Inflammation, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Rongxin Zhang
  • For correspondence: [email protected]
  • Article
  • Figures & Data
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Cheng Y,
    2. He C,
    3. Wang M,
    4. Ma X,
    5. Mo F,
    6. Yang S, et al.
    Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials. Signal Transduct Target Ther. 2019; 4: 62.
    OpenUrl
  2. 2.↵
    1. Zhao S,
    2. Allis CD,
    3. Wang GG.
    The language of chromatin modification in human cancers. Nat Rev Cancer. 2021; 21: 413–30.
    OpenUrlCrossRef
  3. 3.↵
    1. Hanahan D,
    2. Weinberg RA.
    Hallmarks of cancer: the next generation. Cell. 2011; 144: 646–74.
    OpenUrlCrossRefPubMedWeb of Science
  4. 4.↵
    1. Chen JJ,
    2. Wang AQ,
    3. Chen QQ.
    DNA methylation assay for colorectal carcinoma. Cancer Biol Med. 2017; 14: 42–9.
    OpenUrlAbstract/FREE Full Text
  5. 5.↵
    1. Wang S,
    2. Fu J,
    3. Fang X.
    A novel DNA methylation-related gene signature for the prediction of overall survival and immune characteristics of ovarian cancer patients. J Ovarian Res. 2023; 16: 62.
    OpenUrl
  6. 6.↵
    1. Liang WW,
    2. Lu RJ,
    3. Jayasinghe RG,
    4. Foltz SM,
    5. Porta-Pardo E,
    6. Geffen Y, et al.
    Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin. Cancer Cell. 2023; 41: 1567–85.
    OpenUrl
  7. 7.↵
    1. Zhao A,
    2. Zhou H,
    3. Yang J,
    4. Li M,
    5. Niu T.
    Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignancies. Signal Transduct Target Ther. 2023; 8: 71.
    OpenUrl
  8. 8.↵
    1. Zagorac S,
    2. Alcala S,
    3. Fernandez BG,
    4. Bou KT,
    5. Schoenhals M,
    6. Gonzalez-Neira A, et al.
    DNMT1 inhibition reprograms pancreatic cancer stem cells via upregulation of the miR-17-92 cluster. Cancer Res. 2016; 76: 4546–58.
    OpenUrlAbstract/FREE Full Text
  9. 9.↵
    1. Lee E,
    2. Wang J,
    3. Yumoto K,
    4. Jung Y,
    5. Cackowski FC,
    6. Decker AM, et al.
    DNMT1 regulates epithelial-mesenchymal transition and cancer stem cells, which promotes prostate cancer metastasis. Neoplasia. 2016; 18: 553–66.
    OpenUrlCrossRef
  10. 10.↵
    1. Liu R,
    2. Zhao E,
    3. Yu H,
    4. Yuan C,
    5. Abbas MN,
    6. Cui H.
    Methylation across the central dogma in health and diseases: new therapeutic strategies. Signal Transduct Target Ther. 2023; 8: 310.
    OpenUrl
  11. 11.↵
    1. Kiyotani K,
    2. Toyoshima Y,
    3. Nakamura Y.
    Personalized immunotherapy in cancer precision medicine. Cancer Biol Med. 2021; 18: 955–65.
    OpenUrlAbstract/FREE Full Text
  12. 12.↵
    1. Mazor T,
    2. Pankov A,
    3. Song JS,
    4. Costello JF.
    Intratumoral heterogeneity of the epigenome. Cancer Cell. 2016; 29: 440–51.
    OpenUrlCrossRefPubMed
  13. 13.↵
    1. Guo H,
    2. Vuille JA,
    3. Wittner BS,
    4. Lachtara EM,
    5. Hou Y,
    6. Lin M, et al.
    DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs. Cell. 2023; 186: 2765–82.
    OpenUrl
  14. 14.↵
    1. Belk JA,
    2. Daniel B,
    3. Satpathy AT.
    Epigenetic regulation of T cell exhaustion. Nat Immunol. 2022; 23: 848–60.
    OpenUrl
  15. 15.↵
    1. Lai SC,
    2. Su YT,
    3. Chi CC,
    4. Kuo YC,
    5. Lee KF,
    6. Wu YC, et al.
    DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation. J Exp Clin Cancer Res. 2019; 38: 474.
    OpenUrl
  16. 16.↵
    1. Stewart ML,
    2. Tamayo P,
    3. Wilson AJ,
    4. Wang S,
    5. Chang YM,
    6. Kim JW, et al.
    KRAS genomic status predicts the sensitivity of ovarian cancer cells to decitabine. Cancer Res. 2015; 75: 2897–906.
    OpenUrlAbstract/FREE Full Text
  17. 17.↵
    1. Wang N,
    2. Ma T,
    3. Yu B.
    Targeting epigenetic regulators to overcome drug resistance in cancers. Signal Transduct Target Ther. 2023; 8: 69.
    OpenUrl
  18. 18.↵
    1. Zhou S,
    2. Ou H,
    3. Wu Y,
    4. Qi D,
    5. Pei X,
    6. Yu X, et al.
    Targeting tumor endothelial cells with methyltransferase inhibitors: mechanisms of action and the potential of combination therapy. Pharmacol Ther. 2023; 247: 108434.
  19. 19.↵
    1. Li Y,
    2. Porta-Pardo E,
    3. Tokheim C,
    4. Bailey MH,
    5. Yaron TM,
    6. Stathias V, et al.
    Pan-cancer proteogenomics connects oncogenic drivers to functional states. Cell. 2023; 186: 3921–44.
    OpenUrl
  20. 20.↵
    1. Geffen Y,
    2. Anand S,
    3. Akiyama Y,
    4. Yaron TM,
    5. Song Y,
    6. Johnson JL, et al.
    Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation. Cell. 2023; 186: 3945–67.
    OpenUrl
Next
Back to top

In this issue

Cancer Biology & Medicine: 22 (6)
Cancer Biology & Medicine
Vol. 22, Issue 6
15 Jun 2025
  • Table of Contents
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Cancer Biology & Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
DNA methylation profiles in cancer: functions, therapy, and beyond
(Your Name) has sent you a message from Cancer Biology & Medicine
(Your Name) thought you would like to see the Cancer Biology & Medicine web site.
Citation Tools
DNA methylation profiles in cancer: functions, therapy, and beyond
Jinrong Zhu, Yongjie Yang, Li Li, Jiuren Tang, Rongxin Zhang
Cancer Biology & Medicine Dec 2023, 20230403; DOI: 10.20892/j.issn.2095-3941.2023.0403

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
DNA methylation profiles in cancer: functions, therapy, and beyond
Jinrong Zhu, Yongjie Yang, Li Li, Jiuren Tang, Rongxin Zhang
Cancer Biology & Medicine Dec 2023, 20230403; DOI: 10.20892/j.issn.2095-3941.2023.0403
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • DNA methylation in cancer
    • DNA methylation as a cancer biomarker
    • Integrative multi-omic cancer profiling has revealed abnormal DNA methylation patterns and unique epigenetic characteristics in seven tumor types
    • DNMT overexpression frequently contributes to the progression of hematologic malignancies
    • Overexpression of DNMTs increases the potential for solid tumor formation
    • DNMT deficiency induces the CSC phenotype and enhances the epithelial-mesenchymal transition (EMT) in solid tumors
    • DNA methylation inhibition is used for targeted therapy in preclinical cancer treatments
    • Inhibition of DNA methylation enhances intrinsic immune responses and immune cell functions during tumor progression
    • Conclusions
    • Author contributions
    • Conflict of interest statement
    • References
  • Figures & Data
  • Info & Metrics
  • References
  • PDF

Related Articles

  • No related articles found.
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • PI3Kβ moonlights as a protein kinase: driving fatty acid metabolism and histone acetylation in cancer
  • Breast surgeons at the forefront: preserving lymph nodes for enhanced immunotherapy efficacy
  • Dissection of the TNM staging classification for nasopharyngeal cancer – past, present, and future
Show more Editorial

Similar Articles

Navigate

  • Home
  • Current Issue

More Information

  • About CBM
  • About CACA
  • About TMUCIH
  • Editorial Board
  • Subscription

For Authors

  • Instructions for authors
  • Journal Policies
  • Submit a Manuscript

Journal Services

  • Email Alerts
  • Facebook
  • RSS Feeds
  • Twitter

 

© 2025 Cancer Biology & Medicine

Powered by HighWire