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Research ArticleResearch Article

Efficacy and Immune Mechanisms of Cetuximab for the Treatment of Metastatic Colorectal Cancer

Hao ZHUANG, Zhen-yi XUE, Lu WANG, Xiao-yan LI, Ning ZHANG and Rong-xin ZHANG
Clinical Oncology and Cancer Research December 2011, 8 (4) 207-214; DOI: https://doi.org/10.1007/s11805-011-0582-8
Hao ZHUANG
1Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
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Zhen-yi XUE
1Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
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Lu WANG
1Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
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Xiao-yan LI
1Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
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Ning ZHANG
1Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
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Rong-xin ZHANG
1Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
2Department of Immunology, Tianjin Medical University, Tianjin 300070, China
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Cancer Biology and Medicine: 8 (4)
Clinical Oncology and Cancer Research
Vol. 8, Issue 4
1 Dec 2011
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Efficacy and Immune Mechanisms of Cetuximab for the Treatment of Metastatic Colorectal Cancer
Hao ZHUANG, Zhen-yi XUE, Lu WANG, Xiao-yan LI, Ning ZHANG, Rong-xin ZHANG
Clinical Oncology and Cancer Research Dec 2011, 8 (4) 207-214; DOI: 10.1007/s11805-011-0582-8

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Efficacy and Immune Mechanisms of Cetuximab for the Treatment of Metastatic Colorectal Cancer
Hao ZHUANG, Zhen-yi XUE, Lu WANG, Xiao-yan LI, Ning ZHANG, Rong-xin ZHANG
Clinical Oncology and Cancer Research Dec 2011, 8 (4) 207-214; DOI: 10.1007/s11805-011-0582-8
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  • Article
    • Abstract
    • Introduction
    • Mechanisms Underlying the Antitumor Activity of Cetuximab
    • Clinical Efficacy of Cetuximab in mCRC
    • Possible Mechanisms of Nonresponse to Cetuximab and Patient Selection
    • Summary
    • Conflict of Interest Statement
    • Acknowledgments
    • References
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Keywords

  • Colorectal cancer
  • cetuximab
  • epidermal growth factor receptor
  • immune mechanisms
  • prognostic marker
  • EGFR, epidermal growth factor receptor
  • CDC, complement-dependent cytotoxicity
  • mCRC, metastatic colorectal cancer
  • mAb, monoclonal antibody
  • ADCC, antibody-dependent cellular cytotoxicity
  • TA, tumor antigen
  • EGF, epidermal growth factor
  • NK, natural killer (cells)
  • DC, dendritic cells
  • CTL, cytotoxic lymphocyte
  • BSC, best supportive care
  • OS, overall survival
  • PFS, progression-free survival
  • RR, response rate
  • APC, antigen-presenting cell
  • HLA, human leukocyte antigen

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