Research ArticleResearch Article
Efficacy and Immune Mechanisms of Cetuximab for the Treatment of Metastatic Colorectal Cancer
Hao ZHUANG, Zhen-yi XUE, Lu WANG, Xiao-yan LI, Ning ZHANG and Rong-xin ZHANG
Clinical Oncology and Cancer Research December 2011, 8 (4) 207-214; DOI: https://doi.org/10.1007/s11805-011-0582-8
Hao ZHUANG
1Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
Zhen-yi XUE
1Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
Lu WANG
1Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
Xiao-yan LI
1Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
Ning ZHANG
1Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
Rong-xin ZHANG
1Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
2Department of Immunology, Tianjin Medical University, Tianjin 300070, China
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In this issue
Efficacy and Immune Mechanisms of Cetuximab for the Treatment of Metastatic Colorectal Cancer
Hao ZHUANG, Zhen-yi XUE, Lu WANG, Xiao-yan LI, Ning ZHANG, Rong-xin ZHANG
Clinical Oncology and Cancer Research Dec 2011, 8 (4) 207-214; DOI: 10.1007/s11805-011-0582-8
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Keywords
- Colorectal cancer
- cetuximab
- epidermal growth factor receptor
- immune mechanisms
- prognostic marker
- EGFR, epidermal growth factor receptor
- CDC, complement-dependent cytotoxicity
- mCRC, metastatic colorectal cancer
- mAb, monoclonal antibody
- ADCC, antibody-dependent cellular cytotoxicity
- TA, tumor antigen
- EGF, epidermal growth factor
- NK, natural killer (cells)
- DC, dendritic cells
- CTL, cytotoxic lymphocyte
- BSC, best supportive care
- OS, overall survival
- PFS, progression-free survival
- RR, response rate
- APC, antigen-presenting cell
- HLA, human leukocyte antigen