Prognostic and Predictive Factors of Early Breast Cancer

Article Figures & Data

Table 1.

Patients and disease characteristics.

Characteristics	No.(%)
Age, years
< 50	308 (57)
≥ 50	232 (43)
Tumor size (pT)
1a	5 (1)
1b	35 (6)
1c	142 (26)
2	358 (67)
Tumor location
Medial	123 (23)
Central	125 (23)
Lateral	292 (54)
Histology
Ductal	434 (81)
Lobular	3 (0)
Other	103 (19)
Histological grade
Grade I	240 (44)
Grade II	53 (10)
Grade III	247 (46)
Number of positive axillary nodes
None	348 (64)
1-3 nodes	192 (36)
Positive nodes (%)
≤ 20%	533 (99)
> 20%	7 (1)
Estrogen receptor status
Positive	203 (38)
Negative	183 (34)
Unknown	154 (28)
Progesterone receptor status
Positive	196 (36)
Negative	200 (37)
Unknown	144 (27)
Preoperation chemotherapy
Yes	119 (22)
No	421 (78)
Postoperation chemotherapy
Yes	504 (93)
No	36 (7)
Cycles of postoperation chemotherapy
≤ 4	365 (72)
> 4	139 (28)
Radiotherapy
Yes	275 (51)
No	265 (49)
Hormonal therapy
Yes	235 (44)
No	305 (56)

Table 2.

Unadjusted analysis of the effect of variables on 10-year locoregional recurrence (LRR) and distant recurrence (DR).

Characteristics	LRR No. (%)	P	DR No. (%)	P
Age, years		0.83		0.22
< 50	28 (9)		38 (12)
≥ 50	20 (9)		38 (16)
Tumor size (pT)		0.81		0.11
T1	16 (9)		20 (11)
T2	32 (9)		56 (16)
Tumor location		0.21		0.13
Medial	9 (7)		13 (11)
Central	7 (6)		13 (10)
Lateral	32 (11)		50 (17)
Histology		0.84		0.01
Ductal	39 (9)		69 (16)
Non-Ductal	9 (9)		7 (7)
Histological grade		0.92		0.37
Grade I	24 (10)		36 (15)
Grade II	5 (9)		4 (8)
Grade III	19 (8)		36 (15)
No. of positive nodes		0.01		0.03
None	23 (7)		41 (12)
1-3 nodes	25 (13)		35 (18)
Positive nodes (%)		< 0.001		< 0.001
≤ 20%	43 (8)		72 (14)
> 20%	5 (71)		4 (57)
Estrogen receptor status		0.31		0.76
Positive	13 (6)		30 (15)
Negative	20 (11)		29 (16)
Progesterone receptor status		0.77		0.97
Positive	17 (8)		29 (15)
Negative	18 (9)		30 (15)
Preoperation chemotherapy		0.10		0.78
Yes	6 (5)		16 (13)
No	42 (10)		60 (14)
Postoperation chemotherapy		0.22		0.38
Yes	47 (9)		73 (15)
No	1 (3)		3 (8)
Cycles of postoperation chemotherapy		0.66		0.46
≤ 4	35 (10)		18 (13)
> 4	12 (9)		55 (15)
Radiotherapy		0.86		0.42
Yes	23 (9)		35 (13)
No	25 (9)		41 (16)
Hormonal therapy		0.84		0.66
Yes	20 (9)		35 (15)
No	28 (9)		41 (13)

Table 3.

Multivariate Cox regression analysis of 10-year LRR and DR.

	LRR		DR
	Hazard ratio (95% CI)	P	Hazard ratio (95% CI)	P
Number of positive nodes (none vs. 1-3 nodes)	1.643 (0.902-2.994)	0.105	1.426 (0.894-2.275)	0.137
Positive nodes (%) (≤ 20% vs. > 20%)	12.816 (4.657-35.266)	< 0.001	11.088 (3.807-32.297)	< 0.001
Preoperation chemotherapy (yes vs. no)	0.571 (0.241-1.355)	0.204	/	/
Histology (ductal vs. others)	/	/	0.390 (0.179-0.851)	0.018

Table 4.

Unadjusted analysis of the effect of variables on 10-year overall survival (OS) and disease-free survival (DFS).

Characteristics	OS No. (%)	P	DFS No. (%)	P
Age, years		0.85		0.71
< 50	252 (82)		228 (74)
≥ 50	191 (82)		167 (72)
Tumor size (pT)		0.29		0.11
T1	152 (84)		140 (77)
T2	291 (81)		255 (71)
Tumor location		0.52		0.30
Medial	102 (83)		90 (73)
Central	107 (86)		98 (78)
Lateral	234 (80)		207 (71)
Histology		0.52		0.18
Ductal	354 (82)		312 (72)
Non-Ductal	89 (84)		83 (78)
Histological grade		0.35		0.61
Grade I	223 (93)		199 (83)
Grade II	42 (80)		41 (77)
Grade III	178 (72)		155 (63)
Number of positive nodes		< 0.001		0.001
None	303 (87)		272 (78)
1-3 nodes	140 (73)		123 (64)
Positive nodes (%)		< 0.001		< 0.001
≤ 20%	440 (83)		393 (74)
> 20%	3 (43)		2 (29)
Estrogen receptor status		0.68		0.80
Positive	161 (79)		147 (72)
Negative	146 (80)		128 (70)
Progesterone receptor status		0.26		0.42
Positive	166 (85)		146 (75)
Negative	154 (77)		138 (69)
Preoperation chemotherapy		0.28		0.67
Yes	92 (77)		88 (74)
No	351 (83)		307 (73)
Postoperation chemotherapy		0.04		0.39
Yes	418 (83)		371 (74)
No	25 (69)		24 (67)
Cycles of postoperation chemotherapy		0.056		0.11
≤ 4	296 (81)		262 (72)
> 4	122 (88)		109 (78)
Radiotherapy		0.46		0.73
Yes	231 (84)		204 (74)
No	212 (80)		191 (72)
Hormonal therapy		0.56		0.62
Yes	198 (84)		176 (75)
No	245 (80)		219 (72)

Table 5.

Multivariate Cox regression analyis of 10-year OS and DFS.

Variables	OS		DFS
Variables	Hazard ratio (95% CI)	P	Hazard ratio (95% CI)	P
No. of positive nodes (none vs. 1-3 nodes)	2.110 (1.364-3.264)	0.001	1.634 (1.171-2.279)	0.004
Positive nodes ≤ 20% vs. > 20%)	12.816 (4.657-35.266)	< 0.001	7.339 (2.906-18.530)	< 0.001
Postoperation chemotherapy (yes vs. no)	NS	NS	/	/
Cycles of postchemotherapy (yes vs. no)	0.646 (0.378-1.104)	0.110	/	/