The Relationship between a Cohort Endoscopic Screening of 15,000 Subjects and the Death of Patients with Esophageal and Gastric Cancers in High-Risk Areas

Article Figures & Data

Table 1.

Pathology results of precancerous lesions and cancer from endoscopic screening

		Pathologic diagnoses of esophageal lesions					Pathologic diagnoses of cardiac lesions
Group	Cases	Severe atypical hyperplasia	Carcinoma in situ	Intramucosal carcinoma	Infiltrating carcinoma	Total	Severe atypical hyperplasia	Intramucosal carcinoma	Infiltrating carcinoma	Total
Male	1642	53	36	13	9	111	15	5	15	35
Female	1690	38	35	6	9	88	6	2	5	13
Total	3332	91	71	19	18	199	21	7	20	48

Table 2.

Analysis of the deaths of male EC patients from the cohort screening population.

Age (years)	IVG			CG			Statistics
Age (years)	Population	Death toll in EC cases	Death rate (%)	Population	Death toll in EC cases	Death rate (%)	RR	95% (CI)	P
40-	903	5	0.55	858	10	1.17	0.47	0.16-1.39	0.163
45-	761	12	1.58	1190	25	2.1	0.75	0.37-1.50	0.408
50-	552	15	2.72	894	25	2.8	0.97	0.51-1.86	0.929
55-	407	18	4.42	554	31	5.6	0.78	0.43-1.42	0.414
60-	331	20	6.04	396	35	8.84	0.66	0.38-1.17	0.156
65-69	303	26	8.58	407	40	9.83	0.86	0.51-1.45	0.571
Total	3257	96	2.98	4299	166	3.86	0.76	0.59-0.98	0.038

There was a downtrend in the RR of EC in the male populations from various age groups of the IVG, compared with that in the CG. The overall RR value was 0.76, and there was a statistically significant difference between the two groups.

Table 3.

Analysis of female EC deaths from the cohort screening population.

Age (years)	IVG			CG			Total
Age (years)	Population	EC death	Death rate (%)	Population	EC death	Death rate (%)	RR	95% (CI)	P
40-	931	1	0.11	823	3	0.36	0.29	0.03-2.83	0.259
45-	801	4	0.5	1222	8	0.65	0.61	0.18-2.03	0.414
50-	575	5	0.87	933	22	2.36	0.36	0.14-0.97	0.034
55-	401	12	2.99	626	25	3.99	0.74	0.37-1.49	0.401
60-	380	8	2.11	451	14	3.1	0.67	0.28-1.62	0.372
65-69	251	6	2.39	375	21	5.6	0.41	0.16-1.04	0.053
Total	3339	36	1.08	4430	93	2.1	0.51	0.35-0.75	0.000

There was also a downtrend in the RR of EC in the female populations from various age groups of the IVG, compared with that in the CG. This is especially pronounced in the population of the 50-year age group, with a 54% decrease in the RR, and a significant difference between the IVG and the CG. There was a 49% decrease in the overall RR value, P = 0.000.

Table 4.

Analysis of male GC deaths from the cohort screening population.

Age (years)	IVG	CGC	Distal GC	Uncertain site	Total	Death rate (%)	CG	CGC	Distal GC	Uncertain site	Total	Canceration rate (%)	RR	95% (CI)	P
40-	903	1	1	1	3	0.33	858	1	1	-	2	0.23	1.43	0.24-8.56	0.696
45-	761	2	1	1	4	0.53	1190	1	0	-	1	0.08	6.28	0.76-56.32	0.060
50-	552	2	1	2	5	0.91	894	2	1	-	3	0.34	2.72	0.65-11.41	0.156
55-	407	1	2	-	3	0.74	554	0	3	-	3	0.54	1.36	0.27-6.79	0.704
60-	331	8	1	-	9	2.72	396	1	1	2	4	1.01	2.74	0.84-8.98	0.083
65-69	303	7	4	-	11	3.63	407	3	2	1	6	1.47	2.54	0.93-6.94	0.061
Total	3257	21	10	4	35	1.07	4299	8	8	3	19	0.44	2.45	1.40-4.29	0.010

In the comparison of the death rates of GC in males of various age groups between the IVG and the CG, the RR value ranged from 1.43 to 6.28, without significant differences between the groups. The total RR of death = 2.45, P = 0.010.

Table 5.

Analysis of female GC deaths from the cohort screening population.

Age (years)	IVG	CGC	Distal GC	Uncertain site	GC	Death rate (%)	CG	CGC	Distal GC	Uncertain site GC	Death rate (%)	RR	95% (CI)	P
40-	931	0	0	-	0	0.00	823	1	2	-3	0.36	-	-	-
45-	801	1	1	-	2	0.25	1222	0	0	-0	0.00	-	-
50-	575	1	1	1	3	0.52	933	2	1	-3	0.32	1.63	0.33-8.08	0.549
55-	401	0	0	-	0	0.00	626	0	2	-2	0.32	-	-	-
60-	380	3	0	-	3	0.79	451	1	4	-5	1.11	0.71	0.17-2.89	0.639
65-69	251	4	1	-	5	1.99	375	2	3	-5	1.33	1.50	0.43-5.25	0.519
Total	3339	9	3	1	13	0.39	4430	6	12	- 18	0.41	0.99	0.47-1.99	0.906

In the comparison of the death rates of GC in the females of 50 and 65-year age groups between the IVG and the CG, the RR value ranged from 1.50 to 1.63, without significant differences between the groups. The total RR of death = 0.99, P = 0.906.