Evaluate the Expression of uPA, PAI-1 in Human Gastric Cancer and its Correlation with the Angiogenesis by the Application of Tissue Microarray

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Fig. 1.
The expression of uPAmRNA is moderate positive in papillary adenocarcinoma × 100.
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Fig. 2.
The expression of uPA protein is strong positive in tubular adenocarcinoma × 100.
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Fig. 3.
The expression of PAI-1mRNA is moderate positive in poor differenciated adenocarcinoma × 100.
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Fig. 4.
The expression of PAI-1 protein is strong positive in mucoid adenocarcinoma × 100.

Table 1.

The expression of uPA, PAI-1 mRNA and protein in histologic differentiation of GC.

Group	n	uPAmRNA (protein)^{^a}				PAI-1 mRNA (protein)^{^b}
Group	n	-	±	+	Positive %	-	±	+	Positive %
I	9	0 (0)	5 (3)	4 (6)	44.4^(66.7)^	0 (0)	4 (2)	5 (7)	54.6^(77.8)^
II	39	5 (3)	13 (13)	21 (23)	53.8 (60.0)	3 (1)	13 (12)	23 (26)	60.0 (66.7)
III	62	15 (10)	10 (7)	37 (45)	59.7 (72.6)	16 (13)	13 (9)	33 (40)	53.2 (64.5)

Comparison among the groups of GC
↵* P<0.05
↵a The relationship between the expressions of uPA mRNA and protein was significantly positive, r =0.686, P < 0.001
↵b The relationship between the expressions of PAI-1 mRNA and protein was significantly positive, r = 0.812, P < 0.001.

Table 2.

Relationship between the expression of uPA, PAI-1 and the MVD.

Group	n	MVD()	P
uPA mRNA (protein)			0.000 (0.003)
-	20 (13)	22.8 ± 3.1 (22.7 ± 3.8)
±	28 (23)	23.4 ± 2.6 (24.4 ± 2.6)
+	62 (74)	27.5 ± 4.1 (26.5 ± 4.4)
PAI mRNA (protein)			0.560 (0.672)
-	18 (14)	24.7 ± 5.8 (26.5 ± 6.2)
±	28 (23)	25.2 ± 4.0 (25.6 ± 3.6)
+	64 (73)	25.9 ± 4.0 (25.4 ± 4.0)

Table 3.

Relationship between the expression of uPA, PAI-1, MVD and clinicopathological parameters in GC.

Parameters	n	MVD	uPA positive		PAI-1 positive
Parameters	n	MVD	mRNA (%)	Protein (%)	mRNA (%)	Protein (%)
Clinical stage
I-II	21	22.9 ± 3.1^*	7 (33.3)	9 (42.9)^*	7 (33.3)	14 (66.7)
III-IV	89	26.2 ± 4.2	55 (61.8)	65 (73.1)	57 (64.0)	59 (66.3)
Lymph node metastasis
Absent	37	24.9 ± 3.8	16 (43.2)	23 (62.2)	16 (43.2)	26 (70.3)
Present	73	25.9 ± 4.4	46 (63.0)	51 (69.9)	48 (65.8)	47 (64.4)