HIF-1α siRNA Leads to Apoptosis of Pancreatic Cancer Cells under Hypoxic Conditions

References

1. ↵
   1. Yin T,
   2. Wang C,
   3. Liu T, et al.

   Expression of snail in pancreatic cancer promotes metastasis and chemoresistance. J Surg Res 2007; 141: 196-203.

   OpenUrlCrossRefPubMedWeb of Science
2. ↵
   1. Brizel DM,
   2. Scully SP,
   3. Harrelson JM, et al.

   Tumor oxygenation predicts for the likelihood of distant metastasis in human soft tissue sarcoma. Cancer Res 1996; 56: 941-943.

   OpenUrlAbstract/FREE Full Text
3. ↵
   1. Semenza GL.

   Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3: 721-732.

   OpenUrlCrossRefPubMedWeb of Science
4. ↵
   1. Wang GL,
   2. Jiang BH,
   3. Rue EA, et al.

   Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 1995; 92: 5510-5514.

   OpenUrlAbstract/FREE Full Text
5. ↵
   1. Masson N,
   2. Willam C,
   3. Maxwell PH, et al.

   Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation. EMBO J 2001; 20: 5197-5206.

   OpenUrlAbstract/FREE Full Text
6. ↵
   1. Huang LE,
   2. Gu J,
   3. Schau M, et al.

   Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 1998; 95: 7987-7992.

   OpenUrlAbstract/FREE Full Text
7. ↵
   1. Jiang BH,
   2. Rue E,
   3. Wang GL, et al.

   Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem 1996; 271: 17771-17778.

   OpenUrlAbstract/FREE Full Text
8. ↵
   1. Büchler P,
   2. Reber HA,
   3. Büchler M, et al.

   Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer. Pancreas 2003; 26: 56-64.

   OpenUrlCrossRefPubMedWeb of Science
9. 1. Lu H,
   2. Forbes RA,
   3. Verma A.

   Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J Biol Chem 2002; 26: 23111-23115.

   OpenUrl
10. ↵
    1. Wang F,
    2. Li SS,
    3. Segersvard R, et al.

    Hypoxia inducible factor-1 mediates effects of insulin on pancreatic cancer cells and disturbs host energy homeostasis. Am J Pathol 2007; 170: 469-477.

    OpenUrlCrossRefPubMed
11. ↵
    1. Zhong H,
    2. De Marzo AM,
    3. Laughner E, et al.

    Overexpression of hypoxia-inducible factor-1α in common human cancers and their metastases. Cancer Res 1999; 59: 5830-5835.

    OpenUrlAbstract/FREE Full Text
12. ↵
    1. Wu XB,
    2. Dong XY,
    3. Wu ZJ, et al.

    A novel method for purification of recombinant adeno-associated virus vectors in large-scale. Chin Sci Bull 2001; 46: 485-489.

    OpenUrlCrossRef
13. ↵
    1. Semenza GL.

    HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 2000; 88: 1474-1480.

    OpenUrlCrossRefPubMedWeb of Science
14. ↵
    1. Epstein ACR,
    2. Gleadle GM,
    3. McNeill LA, et al.

    C elegans EGL-9 and mammalian homologues define a family of dioxygenases that regulate HIF by prolyl hydroxylation Cell 2001; 107: 43-54.

    OpenUrlCrossRefPubMedWeb of Science
15. ↵
    1. Bruick KB,
    2. McKnight SL.

    A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001; 294: 1337-1340.

    OpenUrlAbstract/FREE Full Text
16. 1. Hewitson KS,
    2. McNeill LA,
    3. Riordan MV, et al.

    Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J Biol Chem 2002; 277: 26351-26355.

    OpenUrlAbstract/FREE Full Text
17. ↵
    1. Lando D,
    2. Peet DJ,
    3. Gorman JJ, et al.

    FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 2002; 16: 1466-71.

    OpenUrlAbstract/FREE Full Text
18. ↵
    1. Maxwell PH,
    2. Pugh CW,
    3. Ratcliffe PJ.

    The pVHL-hIF-1 system. A key mediator of oxygen homeostasis. Adv Exp Med Biol 2001; 502: 365-376.

    OpenUrlCrossRefPubMedWeb of Science
19. ↵
    1. Tanimoto K,
    2. Makino Y,
    3. Pereira T, et al.

    Michanism of regulation of the hypoxia inducible factor 1 α by the vhippel-lindau tumor suppressor protein. EMBO J 2000; 19: 4298-4309.

    OpenUrlAbstract/FREE Full Text
20. ↵
    1. Kwon SJ,
    2. Lee YJ.

    Effect of low glutamine/glucose on hypoxia-induced elevation of hypoxia-inducible factor-1α in human pancreatic cancer MiaPaCa-2 and human prostatic cancer DU-145 cells. Clin Cancer Res 2005; 11: 4694-4700.

    OpenUrlAbstract/FREE Full Text
21. ↵
    1. Li QF,
    2. Wang XR,
    3. Yang YW, et al.

    Hypoxia upregulates hypoxia inducible factor (HIF)-3α expression in lung epithelial cells: characterization and comparison with HIF-1α. Cell Res 2006; 16: 548-558.

    OpenUrlCrossRefPubMedWeb of Science
22. ↵
    1. Yu L,
    2. Liu Y,
    3. Cui Y.

    Expression of hypoxia inducible factor-1α and its relationship to apoptosis and proliferation in human laryngeal squamous cell carcinoma. J Huazhong Univ Sci Technolog Med Sci 2004; 24: 636-638 (Chinese).

    OpenUrlCrossRefPubMed
23. ↵
    1. Fan LF,
    2. Diao LM,
    3. Chen DJ, et al.

    Expression of HIF-1 α and its relationship to apoptosis and proliferation in lung cancer. Ai Zheng 2002; 21: 254-258 (Chinese).

    OpenUrlPubMed
24. ↵
    1. Zamore PD.

    RNA interference: listening to the sound of silence. Nat Struct Biol 2001; 8: 746-751.

    OpenUrlCrossRefPubMedWeb of Science
25. ↵
    1. Tomar RS,
    2. Matta H,
    3. Chaudhary PM.

    Use of adeno-associated viral vector for delivery of small interfering RNA. Oncogene 2003; 22: 5712-5715.

    OpenUrlCrossRefPubMedWeb of Science
26. ↵
    1. Stilwell JL,
    2. Samulski RJ.

    Adeno-associated virus vectors for therapeutic gene transfer. Biotechniques 2003; 34: 148-150.

    OpenUrlPubMed