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Research ArticleResearch Article

Clinical Implications of HER-2 and P53 in Taxane-Based and Anthracycline-Based Neoadjuvant Chemotherapy in Breast Cancer

Xiaolan Wang, Fan Yao, Nan Liu, Yunfei Wu, Xinyu Zheng, Jiguang Li, Caigang Liu, Xueshan Qiu and Feng Jin
Chinese Journal of Clinical Oncology December 2008, 5 (6) 424-428; DOI: https://doi.org/10.1007/s11805-008-0424-5
Xiaolan Wang
1Department of Surgical Oncology Department of General Surgery;
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Fan Yao
1Department of Surgical Oncology Department of General Surgery;
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Nan Liu
2Department of Pathology, the First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
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Yunfei Wu
1Department of Surgical Oncology Department of General Surgery;
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Xinyu Zheng
1Department of Surgical Oncology Department of General Surgery;
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Jiguang Li
1Department of Surgical Oncology Department of General Surgery;
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Caigang Liu
1Department of Surgical Oncology Department of General Surgery;
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Xueshan Qiu
2Department of Pathology, the First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
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Feng Jin
1Department of Surgical Oncology Department of General Surgery;
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  • For correspondence: jinfeng66cn{at}hotmail.com
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References

  1. ↵
    1. Beriwal S,
    2. Schwartz GF,
    3. Komarnicky L, et al.
    Breastconserving therapy after neoadjuvant chemotherapy: long-term results. Breast J 2006; 2: 159-164.
    OpenUrl
  2. ↵
    1. Fisher B,
    2. Brown A,
    3. Mamounas E, et al.
    Effect of preoperative chemotherapy on local-regional disease in women with operable breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-18. J Clin Oncol 1997; 7: 2483-2493.
    OpenUrl
  3. ↵
    1. Cleator S,
    2. Parton M,
    3. Dowsett M.
    The biology of neoadjuvant chemotherapy for breast cancer. Endocr Relat Cancer 2002; 9: 183-195.
    OpenUrlAbstract
  4. ↵
    1. Crown J,
    2. O’Leary M,
    3. Ooi WS.
    Docetaxel and paclitaxel in the treatment of breast cancer: A review of clinical experience. Oncologist 2004; 9: 24-32.
    OpenUrlAbstract/FREE Full Text
  5. ↵
    1. Petit T,
    2. Borel C,
    3. Ghnassia JP, et al.
    Chemotherapy response of breast cancer depends on HER-2 status and anthracycline dose intensity in the neoadjuvant setting. Clin Cancer Res 2001; 7: 1577-1581.
    OpenUrlAbstract/FREE Full Text
  6. ↵
    1. Petit T,
    2. Wilt M,
    3. Velten M, et al.
    Comparative value of tumour grade, hormonal receptors, Ki-67, HER-2 and topoisomerase II alpha status as predictive markers in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy. Eur J Cancer 2004; 40: 205-211.
    OpenUrlCrossRefPubMedWeb of Science
  7. ↵
    1. Kariya S,
    2. Ogawa Y,
    3. Nishioka A, et al.
    Relationship between hormonal receptors, HER-2, P53 protein, Bcl-2, and MIB-1 status and the antitumor effects of neoadjuvant anthracycline-based chemotherapy in invasive breast cancer patients. Radiat Med 2005; 23: 189-194.
    OpenUrlPubMed
  8. ↵
    1. Kimura M,
    2. Sano M,
    3. Fujimori M, et al.
    Neoadjuvant paclitaxel for operable breast cancer: multicenter phase II trial with clinical outcomes. Anticancer Res 2008; 28: 1239-1244.
    OpenUrlAbstract/FREE Full Text
  9. ↵
    1. Geisler S,
    2. Børresen-Dale AL,
    3. Johnsen H, et al.
    TP53 gene mutations predict the response to neoadjuvant treatment with 5-fluorouracil and mitomycin in locally advanced breast cancer. Clin Cancer Res 2003; 9: 5582-5588.
    OpenUrlAbstract/FREE Full Text
  10. ↵
    1. Rahko E,
    2. Blanco G,
    3. Soini Y, et al.
    A mutant TP53 gene status is associated with a poor prognosis and anthracycline-resistance in breast cancer patients. Eur J Cancer 2003; 39: 447-453.
    OpenUrlCrossRefPubMedWeb of Science
  11. ↵
    1. Bertheau P,
    2. Turpin E,
    3. Rickman DS, et al.
    Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen. PLoS Med 2007; 4: e90.
    OpenUrlCrossRefPubMed
  12. ↵
    1. Bertheau P,
    2. Plassa F,
    3. Espié M, et al.
    Effect of mutated TP53 on response of advanced breast cancers to high-dose chemotherapy. Lancet 2002; 360: 852-854.
    OpenUrlCrossRefPubMedWeb of Science
  13. ↵
    1. Johnson KR,
    2. Fan W.
    Reduced expression of P53 and p21WAF1/CIP1 sensitizes human breast cancer cells to paclitaxel and its combination with 5-fluorouracil. Anticancer Res 2002; 22: 3197-3204.
    OpenUrlPubMedWeb of Science
  14. ↵
    1. Bao H,
    2. Yu D,
    3. Wang J, et al.
    Predictive value of serum anti-P53 antibodies, carcino-embryonic antigen, carbohydrate antigen 15-3, estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 in taxane-based and anthracycline-based neoadjuvant chemotherapy in locally advanced breast cancer patients. Anticancer Drugs 2008; 19: 317-323.
    OpenUrlPubMed
  15. ↵
    1. Kandioler-Eckersberger D,
    2. Ludwig C,
    3. Rudas M, et al.
    TP53 mutation and P53 overexpression for prediction of response to neoadjuvant treatment in breast cancer patients. Clin Cancer Res 2000; 6: 50-56.
    OpenUrlAbstract/FREE Full Text
  16. ↵
    1. Noguchi S.
    Predictive factors for response to docetaxel in human breast cancers. Cancer Sci 2006; 97: 813-820
    OpenUrlCrossRefPubMed
  17. ↵
    1. Reitsamer R,
    2. Peintinger F,
    3. Prokop E, et al.
    Pathological complete response rates comparing 3versus 6 cycles of epidoxorubicin and docetaxel in the neoadjuvant setting of patients with stage II and III breast cancer. Anticancer Drugs 2005; 16: 867-870.
    OpenUrlCrossRefPubMed
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Cancer Biology and Medicine: 5 (6)
Chinese Journal of Clinical Oncology
Vol. 5, Issue 6
1 Dec 2008
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Clinical Implications of HER-2 and P53 in Taxane-Based and Anthracycline-Based Neoadjuvant Chemotherapy in Breast Cancer
Xiaolan Wang, Fan Yao, Nan Liu, Yunfei Wu, Xinyu Zheng, Jiguang Li, Caigang Liu, Xueshan Qiu, Feng Jin
Chinese Journal of Clinical Oncology Dec 2008, 5 (6) 424-428; DOI: 10.1007/s11805-008-0424-5

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Clinical Implications of HER-2 and P53 in Taxane-Based and Anthracycline-Based Neoadjuvant Chemotherapy in Breast Cancer
Xiaolan Wang, Fan Yao, Nan Liu, Yunfei Wu, Xinyu Zheng, Jiguang Li, Caigang Liu, Xueshan Qiu, Feng Jin
Chinese Journal of Clinical Oncology Dec 2008, 5 (6) 424-428; DOI: 10.1007/s11805-008-0424-5
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Keywords

  • breast neoplasms
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  • HER-2
  • P53
  • taxane

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